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681672 Sigma-AldrichWnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem (Wnt/β-catenin Inhibitor, Cardamonin - CAS 19309-14-9 - Calbiochem)
The Wnt/β-catenin Inhibitor, Cardamonin, also referenced under CAS 19309-14-9, controls the biological activity of Wnt/β-catenin. This small molecule/inhibitor is primarily used for Cancer applications.
681673 Sigma-AldrichWnt Antagonist III, Box5 - Calbiochem (Wnt Antagonist III, Box5 - Calbiochem)
Wnt Antagonist III, Box5, is a Wnt-5a-derived hexapeptide that antagonizes Wnt-5a-mediated cellular activities in A2058 and HTB63 melanoma cultures, including migration and invasion.
681668 Sigma-AldrichWnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem (Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem)
A cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor).
681664 Sigma-AldrichWnt Agonist I in DMSO - CAS 853220-52-7 - Calbiochem (Wnt Agonist I in DMSO - CAS 853220-52-7 - Calbiochem)
The Wnt Agonist I in DMSO, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
681665 Sigma-AldrichWnt Agonist - CAS 853220-52-7 - Calbiochem (Wnt Agonist - CAS 853220-52-7 - Calbiochem)
Wnt Agonist, CAS 853220-52-7, is a cell-permeable, potent, and selective activator of Wnt signaling. Does not inhibit the activity of GSK-3β (IC50 greater than 60 µM).
681671 Sigma-AldrichWnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem (Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem)
Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.
681669 Sigma-AldrichWnt Antagonist I, IWR-1-endo - Calbiochem (Wnt Antagonist I, IWR-1-endo - Calbiochem)
Wnt Antagonist I, IWR-1-endo, is a cell-permeable inhibitor of TNKS1/PARP5a (IC₅₀ = 131 nM) & TNKS2/PARP5b (IC₅₀= 56 nM). Suppress Wnt-stimulated transcription activity (IC₅₀ = 180 nM).
681667 Sigma-AldrichWnt Agonist II, SKL2001 - CAS 909089-13-0 - Calbiochem (Wnt Agonist II, SKL2001 - CAS 909089-13-0 - Calbiochem)
Wnt Agonist II, SKL2001, CAS 909089-13-0, upregulates β-catenin-regulated transcription by disrupting β-catenin & Axin interaction. Prevents β-catenin phosphorylation and proteasomal degradation.
412400 Sigma-AldrichIQ-1 - CAS 331001-62-8 - Calbiochem (IQ-1 - CAS 331001-62-8 - Calbiochem)
A cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/β-catenin signaling by targeting the PR72/130 subunit of PP2A and thereby blocking PP2A/Nkd complex formation.
