506181 Sigma-Aldrichp75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem
p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.
More>> p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: TAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
Recommended Products
Overview
| Replacement Information |
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Key Spec Table
| Empirical Formula |
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| C₁₅₀H₂₂₇N₅₇O₃₂S₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 506181-500UGCN | 塑膠安瓿;塑膠針藥瓶 | 500 μg |
| Description | |
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| Overview | The p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system. |
| Catalogue Number | 506181 |
| Brand Family | Calbiochem® |
| Synonyms | TAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic |
| References | |
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| References | Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461. Schwarze, S.R., et al. 1999. Science 285, 1569. |
| Product Information | |
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| ATP Competitive | N |
| Form | Lyophilized solid |
| Formulation | Supplied as a trifluoroacetate salt. |
| Hill Formula | C₁₅₀H₂₂₇N₅₇O₃₂S₂ |
| Chemical formula | C₁₅₀H₂₂₇N₅₇O₃₂S₂ |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Quality Level | MQ100 |
| Biological Information | |
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| Primary Target | Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | H₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH disulfide bond (12-26) |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 506181-500UGCN | 04055977272413 |
Documentation
p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem MSDS
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p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 506181 |
References
| Reference overview |
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| Yamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461. Schwarze, S.R., et al. 1999. Science 285, 1569. |