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692000 ZM 336372 - CAS 208260-29-1 - Calbiochem

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM).

ZM 336372 - CAS 208260-29-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide

Primary Target: Protein kinase c-Raf
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
208260-29-1C₂₃H₂₃N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
692000-1MGCN 塑膠安瓿;塑膠針藥瓶 1 mg
Description
OverviewA potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
Catalogue Number692000
Brand Family Calbiochem®
SynonymsN-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
References
ReferencesHall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.
Product Information
CAS number208260-29-1
ATP CompetitiveY
DeclarationSold under license of PCT Application W098/22,103.
FormOff-white solid
Hill FormulaC₂₃H₂₃N₃O₃
Chemical formulaC₂₃H₂₃N₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetProtein kinase c-Raf
Primary Target IC<sub>50</sub>70 nM against protein kinase c-Raf
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
692000-1MGCN 04055977274561

Documentation

ZM 336372 - CAS 208260-29-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

ZM 336372 - CAS 208260-29-1 - Calbiochem Certificates of Analysis

TitleLot Number
692000

References

Reference overview
Hall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-January-2010 RFH
SynonymsN-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
DescriptionA potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number208260-29-1
Chemical formulaC₂₃H₂₃N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
Toxicity Standard Handling
ReferencesHall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.