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681668 Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem

A cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: QS11, Wnt Pathway Activator II

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
944328-88-5C₃₆H₃₃N₅O₂

Products

Catalogue NumberPackaging Qty/Pack
681668-5MGCN 塑膠安瓿;塑膠針藥瓶 5 mg
Description
OverviewA cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).
Catalogue Number681668
Brand Family Calbiochem®
SynonymsQS11, Wnt Pathway Activator II
References
ReferencesZhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.
Product Information
CAS number944328-88-5
FormPale amber solid
Hill FormulaC₃₆H₃₃N₅O₂
Chemical formulaC₃₆H₃₃N₅O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
681668-5MGCN 04055977260267

Documentation

Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Wnt Synergist, QS11 - CAS 944328-88-5 - Calbiochem Certificates of Analysis

TitleLot Number
681668

References

Reference overview
Zhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-April-2011 RFH
SynonymsQS11, Wnt Pathway Activator II
DescriptionA cell-permeable purine compound that binds ARFGAPs (Kd = 364 and 620 nM for AMAP1 and ARFGAP1, respectively) and acts as a broad specificity ARFGAPs inhibitor (GTPase activating proteins of ADP-ribosylation factor). Shown to synergize with Wnt-3a and specifically activate the canonical Wnt/β-catenin signaling pathway both in vitro (2-, 40-, and 200-fold increase of basal transcription activity by QS11, Wnt-3a, and QS11/Wnt-3a, respectively, in a Super(8X)TOPFlash reporter assay using HEK293 cells) and in vivo (in the induction of Xenopus embryonic axis duplication). Also reported to block the migration of AMAP1-overexpressing MDA-MB-231 cells (86% inhibition at 2.5 µM).
FormPale amber solid
Intert gas (Yes/No) Packaged under inert gas
CAS number944328-88-5
Chemical formulaC₃₆H₃₃N₅O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesZhang, Q., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 7444.