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681671 Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem

Wnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylatio

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Inhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I

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681671
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Overview

Key Spec Table

CAS #Empirical Formula
686770-61-6C₂₂H₁₈N₄O₂S₃

Products

Catalogue NumberPackaging Qty/Pack
681671-10MGCN 塑膠安瓿;塑膠針藥瓶 10 mg
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Description
OverviewA cell-permeable benzothiazolyl-acetamide compound that inhibits the cellular Wnt processing and secretion via selective blockage of MBOAT (membrane-bound O-acyltranferase) family member Porcn- (Porcupine) mediated Wnt palmitoylation. IWP-2 does not affect Wnt/β-catenin signaling pathway in general and, unlike IWR-1-endo (Cat. No. 681669), displays no effect against Wnt-stimulated cellular responses. Also available as a 10 mM solution in DMSO (Cat. No. 506072).
Catalogue Number681671
Brand Family Calbiochem®
SynonymsInhibitor of Wnt Production-2, Wnt Pathway Inhibitor II, Porcn Inhibitor I
References
ReferencesChen, B., et al. 2009. Nature Chem. Biol. 5, 100.
Product Information
CAS number686770-61-6
FormOff-white solid
Hill FormulaC₂₂H₁₈N₄O₂S₃
Chemical formulaC₂₂H₁₈N₄O₂S₃
Quality LevelMQ100
Applications
ApplicationWnt Antagonist II, IWP-2, CAS 686770-61-6, is a cell-permeable inhibitor of Wnt processing and secretion. Selectively blocks PORCN, a membrane-bound O-acyltransferase, & inhibits Wnt palmitoylation.
Biological Information
Purity≥97% by HPLC
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
681671-10MGCN 04055977225198