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508146
Sigma-AldrichWAY-100635 Maleate - CAS 634908-75-1 - Calbiochem
A selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
Catalogue Number
508146
Brand Family
Calbiochem®
Synonyms
5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
References
References
Hunt, G. E. et al. 2011. Brain Res. Bull.86, 65. Caamano, R. I. et al. 2010. J. Exp. Biol.213, 1813. Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol.357, 205. Forster, E. A. et al. 1995. Eur. J. Pharmacol.281, 81.
Hunt, G. E. et al. 2011. Brain Res. Bull.86, 65. Caamano, R. I. et al. 2010. J. Exp. Biol.213, 1813. Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol.357, 205. Forster, E. A. et al. 1995. Eur. J. Pharmacol.281, 81.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
31-October-2013 JSW
Synonyms
5-HT1A Serotonis Receptor Antagonist, WAY-100635 Maleate, WAY 100635, WAY100635
Description
A selective 5-HT1A receptor antagonist (pKi = 7.9-9.2). WAY-100635 has been reported to have good inhibitory action centrally and peripherally (1mg/kg dose in rats) but has low intrinsic effects, making it a silent 5-HT1A receptor antagonist. WAY-100635 displaced specific binding of the 5-HT1A radioligand, [3H]8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), to rat hippocampal membranes with a pIC50 of 8.87. This represented a greater than 100-fold selectivity relative to binding at other 5-HT receptor subtypes and major neurotransmitter receptor, reuptake and ion channel sites. WAY-100635 has been used in a variety of vertebrate species in vivo and in vitro.
Form
Off-white solid
CAS number
634908-75-1
Chemical formula
C₂₅H₃₄N₄O₂·C₄H₄O₄
Structure formula
Purity
≥97% by HPLC
Solubility
H₂O (50 mM). Warming is required for complete solubilization.
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Hunt, G. E. et al. 2011. Brain Res. Bull.86, 65. Caamano, R. I. et al. 2010. J. Exp. Biol.213, 1813. Newman-Tancredi, A. et al. 1998. Naunyn Schmiedebergs Arch. Pharmacol.357, 205. Forster, E. A. et al. 1995. Eur. J. Pharmacol.281, 81.
