662125 Sigma-AldrichUbiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem
The Ubiquitin Isopeptidase Inhibitor I, G5, also referenced under CAS 108477-18-5, controls the biological activity of Ubiquitin Isopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The Ubiquitin Isopeptidase Inhibitor I, G5, also referenced under CAS 108477-18-5, controls the biological activity of Ubiquitin Isopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 108477-18-5 | C₁₉H₁₄N₂O₇S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 662125-10MGCN | 塑膠安瓿;塑膠針藥瓶 | 10 mg |
| Description | |
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| Overview | A cell-permeable cross-conjugated α,β-unsaturated dienone compound that induces caspase activation and apoptosis (IC50 = 1.76 and 1.6 µM in E1A and E1A/C9DN cells, respectively) via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity (IC50 = ~ 30 µM). The cellular expression of Bax and Bak is essential for G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of G5. G5 is more potent than, but otherwise exhibits similar pharmacological effects as, Ubiquitin Isopeptidase Inhibitor II, F6 (Cat. No. 662126). At higher concentrations (5-10 µM), shown to induce necrosis in apoptosis-resistant MEFs-DKO. |
| Catalogue Number | 662125 |
| Brand Family | Calbiochem® |
| Synonyms | 3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one, NSC-144303 |
| References | |
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| References | Fontanini, A., et al. 2009. J. Biol. Chem. 284, 8369. Aleo, E., et al. 2006. Cancer Res. 66, 9235. |
| Product Information | |
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| CAS number | 108477-18-5 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₁₉H₁₄N₂O₇S |
| Chemical formula | C₁₉H₁₄N₂O₇S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 662125-10MGCN | 04055977261226 |
Documentation
Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem MSDS
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Ubiquitin Isopeptidase Inhibitor I, G5 - CAS 108477-18-5 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 662125 |
References
| Reference overview |
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| Fontanini, A., et al. 2009. J. Biol. Chem. 284, 8369. Aleo, E., et al. 2006. Cancer Res. 66, 9235. |