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SCC070 UM-SCC-1 Squamous Carcinoma Cell Line

UM-SCC-1 is a unique human head and neck squamous cell carcinoma (HNSCC) cell line isolated from a tumor located on the floor of the mouth of a male patient and is a suitable in vitro model of H&N carcinoma studies.

UM-SCC-1 Squamous Carcinoma Cell Line MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture
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SCC070
≥1X10⁶ cells/vial   
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Overview

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Explore additional UM-SCC cell lines:
UM-SCC-104 Squamous Carcinoma Cell Line (Catalogue Number SCC072)
UM-SCC-47 Squamous Carcinoma Cell Line (Catalogue Number SCC071)

Key Spec Table

Key Applications
CULT
Description
Catalogue NumberSCC070
DescriptionUM-SCC-1 Squamous Carcinoma Cell Line
Alternate Names
  • University Michigan Squamous Cell Carcinoma
  • UMSCC1
  • H&N squamous cell carcinoma cell line
  • Head and neck squamous cell carcinoma cell line
  • HNSCC
Background InformationAll UM-SCC cell lines were derived in the lab of Dr. Thomas Carey at the University of Michigan and are exclusively distributed by Merck KGaA. Access to UM-SCC cells is limited solely to those officers, employees and students of PURCHASER’s institution who need access to perform research. PURCHASER may not distribute UM-SCC cells or derivatives to third parties. PURCHASER shall comply with all applicable laws in its use and handling of the Product and shall keep it under reasonable safe and secure conditions to prevent unauthorized use or access.

THIS PRODUCT IS ONLY AVAILABLE FOR SALE TO ACADEMIC INSTITUTIONS OR NOT-FOR-PROFIT ENTITIES FOR USE UNDER THIS LIMITED USE LABEL LICENSE. FOR INFORMATION ON COMMERCIAL LICENSING OF UM-SCC CELLS, INCLUDING LICENSING TO COMMERCIAL ENTITIES, PLEASE CONTACT: licensing@emdmillipore.com

Head and neck squamous cell carcinoma (HNSCC) develops from the mucosal linings of the upper aerodigestive tract, comprising 1) the nasal cavity and paranasal sinuses, 2) the nasopharynx, 3) the hypopharynx, larynx, and trachea, and 4) the oral cavity and oropharynx. Squamous cell carcinoma (SCC) is the most frequent malignant tumor of the head and neck region. HNSCC is the sixth leading cancer by incidence worldwide. There are 500,000 new cases a year worldwide and two thirds occur in industrialized nations. It is caused by tobacco and alcohol consumption and infection with high-risk types of human papillomavirus (HPV). SCC often develops from preexisting dysplastic lesions. The five-year survival rate of patients with HNSCC is about 40-50%.

UM-SCC-1 is a unique head and neck squamous carcinoma cell line isolated from the tumor located on the floor of the mouth of a male patient. The cell line is negative for HPV-16 and for HLA-A2, a class I molecule of the major histocompatibility complex (MHC). The UM-SCC-1 cell line is 50% more invasive in vitro and displays a greater propensity for perineural and lymphatic invasion in vivo.

UM-SCC-1 was established at the University of Michigan (1) with written informed consent obtained from the patient and with the approval of the study by the Medical School Institutional Review Board.

Reference:
1) Carey, T., et al. (2012) Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines. Head Neck. 2010 April; 32(4): 417–426.
References
Product Information
Components
  • 1) ≥1X106 viable UM-SCC-1 Squamous Carcinoma Cells: (Catalog No. SCC070). Store in liquid nitrogen.
Quality LevelMQ100
Applications
ApplicationUM-SCC-1 is a unique human head and neck squamous cell carcinoma (HNSCC) cell line isolated from a tumor located on the floor of the mouth of a male patient and is a suitable in vitro model of H&N carcinoma studies.
Key Applications
  • Cell Culture
Application NotesThis product is available for sale to academic institutions or not-for-profit entities for research use. For information on commercial licensing please contact licensing@emdmillipore.com.
Biological Information
Cell Line Type
  • Cancer Cells
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assurance• Each vial contains ≥ 1X106 viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negatrive for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsUM-SCC-1 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
Packaging Information
Material Size≥1X10⁶ cells/vial
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
SCC070 04055977179583