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654256 TNF-α Inhibitor - CAS 1049741-03-8 - Calbiochem

The TNF-α Inhibitor, also referenced under CAS 1049741-03-8, controls the biological activity of TNF-α.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, TNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor

Primary Target: TNF-α
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654256
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Overview

Key Spec Table

CAS #Empirical Formula
1049741-03-8C₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O

Products

Catalogue NumberPackaging Qty/Pack
654256-5MGCN 塑膠安瓿;塑膠針藥瓶 5 mg
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Description
OverviewA cell-permeable indolyl-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 µM). Shown to selectively inhibit TNF-α-, but not IL-1β-induced IκB-α degradation in HeLa cells (IC50 = 4.6 µM).
Catalogue Number654256
Brand Family Calbiochem®
Synonyms6,7-Dimethyl-3-((methyl-(2-(methyl-(1-(3-trifluoromethyl-phenyl)-1H-indol-3-ylmethyl)-amino)-ethyl)-amino)-methyl)-chromen-4-one, diHCl, TNF-α Inhibitor, Tumor Necrosis Factor-α Inhibitor
References
ReferencesHe, M.M., et al. 2005. Science 310, 1022.
Product Information
CAS number1049741-03-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
Chemical formulaC₃₂H₃₂F₃N₃O₂ • 2HCl • 1/2H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetTNF-α
Primary Target IC<sub>50</sub>22 µM for non-covalently binding to the TNF-α trimer and promoting subunit dissociation and preventing TNF-α binding to its receptor
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
654256-5MGCN 04055977184631