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530409 TLR8 Agonist, cpd14b - CAS 1607440-08-3 - Calbiochem

A potent agonist of Toll-like receptor 8 agonist (TLR8, EC₅₀ = 200 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Toll-Like Receptor 8 Agonist

Primary Target: TLR8
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1607440-08-3C₁₄H₁₈N₂

Products

Catalogue NumberPackaging Qty/Pack
5.30409.0001 玻璃瓶 10 mg
Description
OverviewA pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number530409
Brand Family Calbiochem®
SynonymsToll-Like Receptor 8 Agonist
References
ReferencesKokatla, H. P., et al. 2014, ChemMedChem9, 719.
Product Information
CAS number1607440-08-3
FormWhite powder
Hill FormulaC₁₄H₁₈N₂
Chemical formulaC₁₄H₁₈N₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetTLR8
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5.30409.0001 04055977260793

Documentation

TLR8 Agonist, cpd14b - CAS 1607440-08-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Kokatla, H. P., et al. 2014, ChemMedChem9, 719.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-June-2014 JSW
SynonymsToll-Like Receptor 8 Agonist
DescriptionA pentyl-quinoline derived compound that acts as a pure, potent agonist of Toll-like receptor 8 agonist (TLR8, EC50 = 200 nM in a human TLR8-specifc reporter gene assay). Does not affect TLR2, 3, 4, 5, 7, 9, 10, Nod1 and Nod2, and is devoid of any TLR7 activity. Shown to induce activities of several cytokines and chemokines, including IL-1a, IL-1b, IL-6, IL-8, IL-10, IL12, IL-18, IFN-g, CCL20, RANTES, GRO, GM-CSF, and Eotaxin (~ 10 mg/ml).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1607440-08-3
Chemical formulaC₁₄H₁₈N₂
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKokatla, H. P., et al. 2014, ChemMedChem9, 719.