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574711 Syk Inhibitor - CAS 622387-85-3 - Calbiochem

The Spleen Tyrosine Kinase Inhibitor, also referenced under CAS 622387-85-3, controls the biological activity of Spleen Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Syk Inhibitor - CAS 622387-85-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Spleen Tyrosine Kinase Inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide

Primary Target: Syk
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
622387-85-3C₁₈H₁₅N₃O₃S

Products

Catalogue NumberPackaging Qty/Pack
574711-5MGCN 玻璃瓶 5 mg
Description
OverviewA cell-permeable oxindole compound that acts as a potent, reversible, and ATP-competitive Syk inhibitor (IC50 = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).
Catalogue Number574711
Brand Family Calbiochem®
SynonymsSpleen Tyrosine Kinase Inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
References
ReferencesLai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3111.
Product Information
CAS number622387-85-3
ATP CompetitiveY
FormDeep orange solid
Hill FormulaC₁₈H₁₅N₃O₃S
Chemical formulaC₁₈H₁₅N₃O₃S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSyk
Primary Target IC<sub>50</sub>14 nM; EC50 = 313 nM against FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3
Purity≥97% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
574711-5MGCN 04055977189667

Documentation

Syk Inhibitor - CAS 622387-85-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Syk Inhibitor - CAS 622387-85-3 - Calbiochem Certificates of Analysis

TitleLot Number
574711

References

Reference overview
Lai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3111.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-January-2010 RFH
SynonymsSpleen Tyrosine Kinase Inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
DescriptionA cell-permeable, potent, reversible, and ATP-competitive Spleen Tyrosine Kinase (Syk) inhibitor (IC50 = 14 nM). Shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC50 = 313 nM).
FormDeep orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number622387-85-3
Chemical formulaC₁₈H₁₅N₃O₃S
Structure formulaStructure formula
Purity≥97% by HPLC (sum of two isomers)
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3111.