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567616 Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem

Sodium 4-Phenylbutyrate, CAS 1716-12-7, is a novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BDK Inhibitor I, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I

Primary Target: Anti-neoplastic agent
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567616
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1716-12-7C₁₀H₁₁O₂Na

Products

Catalogue NumberPackaging Qty/Pack
567616-100MGCN 塑膠安瓿;塑膠針藥瓶 100 mg
Description
OverviewA novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Increases fetal hemoglobin production in vitro and in vivo.
Catalogue Number567616
Brand Family Calbiochem®
SynonymsSPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BDK Inhibitor I, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I
References
ReferencesTso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
Ozcan, U., et al. 2006. Science 313, 1137.
Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
Collins, A.F., et al. 1995. Blood 85, 43.
Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.
Product Information
CAS number1716-12-7
ATP CompetitiveN
FormWhite to slightly yellow solid
Hill FormulaC₁₀H₁₁O₂Na
Chemical formulaC₁₀H₁₁O₂Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSodium 4-Phenylbutyrate, CAS 1716-12-7, is a novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation.
Biological Information
Primary TargetAnti-neoplastic agent
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
567616-100MGCN 04055977266818

Documentation

Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem Certificates of Analysis

TitleLot Number
567616

References

Reference overview
Tso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
Ozcan, U., et al. 2006. Science 313, 1137.
Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
Collins, A.F., et al. 1995. Blood 85, 43.
Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-January-2024 JSW
SynonymsSPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BDK Inhibitor I, BCKD Kinase Inhibitor I, Branched-Chain α-Ketoacid Dehydrogenase Kinase Inhibitor I
DescriptionAn antineoplastic agent that demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines. Acts as an inducer of tumor cytostasis and differentiation as well as of peroxisomal proliferation. A more effective inhibitor of histone deacetylase and inducer of histone acetylation than its structural analogs including 2- and 3-phenylbutyrate. Acts as a transcriptional regulator and improve the targeting of δF508-CFTR (cystic fibrosis transmembrane regulator) for ubiquitination and degradation by reducing the expression of HSC70 in epithelial cells. Also, reported to increase fetal hemoglobin production in vitro and in vivo.
FormWhite to slightly yellow solid
CAS number1716-12-7
Chemical formulaC₁₀H₁₁O₂Na
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTso, S.C., et al. 2013. Proc. Natl. Acad. Sci. USA 110, 9728.
Ozcan, U., et al. 2006. Science 313, 1137.
Carducci, M.A., et al. 2001. Clin. Cancer Res. 7, 3047.
Rubenstein, R.C. and Zeitlin, P.L. 2000. Am.J. Physiol. Cell. Physiol. 278, C259.
Lea, M.A., et al. 1999. Anticancer Res. 19, 1971.
Miller, A.C., et al. 1997. Int. J. Radiat. Biol. 72, 211.
Rubenstein, R.C., et al. 1997. J. Clin. Invest. 100, 2457.
Pineau, T., et al. 1996. Biochem. Pharmacol. 52, 659.
Collins, A.F., et al. 1995. Blood 85, 43.
Lea, M.A., et al. 1995. Anticancer Res. 15, 879.
Figg, W.D., et al. 1994. Anticancer Drugs 5, 336.
Liu, L., et al. 1994. J. Invest. Dermatol. 103, 335.