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573099 STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem

STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

Primary Target: STAT3
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
19983-44-9C₈H₅NO₄S

Products

Catalogue NumberPackaging Qty/Pack
573099-25MGCN Plastic Bag(s) 25 mg
Description
OverviewA cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
Catalogue Number573099
Brand Family Calbiochem®
Synonyms6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
References
ReferencesSchust, J., et al. 2006. Chem. Biol. 13, 1235.
Product Information
CAS number19983-44-9
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₈H₅NO₄S
Chemical formulaC₈H₅NO₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetSTAT3
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573099-25MGCN 07790788051754

Documentation

STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem Certificates of Analysis

TitleLot Number
573099

References

Reference overview
Schust, J., et al. 2006. Chem. Biol. 13, 1235.

Brochure

Title
Pathways and Biomarkers of JAK/STAT Signaling

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-June-2007 JSW
Synonyms6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
DescriptionA cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number19983-44-9
Chemical formulaC₈H₅NO₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
Toxicity Irritant
ReferencesSchust, J., et al. 2006. Chem. Biol. 13, 1235.