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851009 PyBOP

PyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.

PyBOP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 128625-52-5 Molar Mass: 520.39 g/mol Hill Formula: C₁₈H₂₈N₆OP * F₆P
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
128625-52-5C₁₈H₂₈N₆OP * F₆P520.39 g/mol

Products

Catalogue NumberPackaging Qty/Pack
8.51009.0025 塑膠瓶 25 g
8.51009.0100 塑膠瓶 100 g
8.51009.0500 塑膠瓶 500 g
8.51009.1000 塑膠瓶 1 kg
Description
Catalogue Number851009
Replaces01-62-0016
Brand Family Novabiochem®
Alternate Names
  • Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
Background InformationThe standard in situ coupling reagent for solid phase peptide synthesis [1-5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

The product number for this product was previously 01-62-0016.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
References
Product Information
CAS number128625-52-5
Hill FormulaC₁₈H₂₈N₆OP * F₆P
Molar Mass520.39 g/mol
HS Code2933 99 80
Structure formula ImageStructure formula Image
Quality LevelMQ400
Applications
ApplicationPyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.
Biological Information
Physicochemical Information
Density1.438 g/cm3 (20 °C)
Melting Point140 - 155 °C
Vapor pressure<1 hPa (25 °C)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Hazard Pictogram(s) Hazard Pictogram(s)
Hazard Pictogram(s)
Hazard Statement(s)H302: Harmful if swallowed.
H317: May cause an allergic skin reaction.
H410: Very toxic to aquatic life with long lasting effects.
Precautionary Statement(s)P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264: Wash skin thoroughly after handling.
P273: Avoid release to the environment.
P280: Wear protective gloves.
P301 + P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.
P302 + P352: IF ON SKIN: Wash with plenty of water.
Signal WordWarning
Storage class10 - 13 Other liquids and solids
WGKWGK 3 highly hazardous to water
Safety Information
Categories of dangerirritant
Product Usage Statements
Storage and Shipping Information
StorageStore at +2°C to +8°C.
Packaging Information
Transport Information
Declaration (railroad and road) ADR, RIDUN 3077 , 9, III
Declaration (transport by air) IATA-DGRUN 3077 , 9, III
Declaration (transport by sea) IMDG-CodeUN 3077 , 9, III, Marine Pollutant: P
Supplemental Information
Specifications
Color (visual)white to slight yellow to beige
Appearance of substance (visual)powder
Identity (IR)passes test
Assay (HPLC, area%)≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF)clearly soluble
Global Trade Item Number
Catalogue Number GTIN
8.51009.0025 04027269081089
8.51009.0100 04027269081096
8.51009.0500 04027269178611
8.51009.1000 04027269131296

Documentation

PyBOP MSDS

Title

Safety Data Sheet (SDS) 

PyBOP Certificates of Analysis

Product Number PackagingSpecificationLot Number
8.51009.0025 塑膠瓶PDF Specification Document
8.51009.0100 塑膠瓶PDF Specification Document
8.51009.0500 塑膠瓶PDF Specification Document
8.51009.1000 塑膠瓶PDF Specification Document

Brochure

Title
Novabiochem Coupling Reagent Flyer 2010
Novabiochem Innovations 02/06
Novabiochem Innovations 03/10
Novabiochem Letters 01/14

Citations

Title
  • [1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
  • [2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
  • [3] G. B. Fields, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium', R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
  • [4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
  • [5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.