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539690 Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem

The Protein Synthesis Initiation Inhibitor, NSC 119889 blocks 5'-mediated/cap-dependent initiation of protein synthesis. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3,4,5,6-Tetrabromofluorescein

Primary Target: human arginine methyl transferase
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₀H₈Br₄O₅

Products

Catalogue NumberPackaging Qty/Pack
539690-25MGCN 塑膠安瓿;塑膠針藥瓶 25 mg
Description
OverviewA cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5’-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
Catalogue Number539690
Brand Family Calbiochem®
Synonyms3,4,5,6-Tetrabromofluorescein
References
ReferencesNovac, O., et al. 2004. Nucleic Acids Res. 32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.
Product Information
ATP CompetitiveN
FormLight brown solid
Hill FormulaC₂₀H₈Br₄O₅
Chemical formulaC₂₀H₈Br₄O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targethuman arginine methyl transferase
Primary Target IC<sub>50</sub>1.41 µM against human arginine methyl transferase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
539690-25MGCN 04055977194227

Documentation

Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Protein Synthesis Initiation Inhibitor, NSC 119889 - Calbiochem Certificates of Analysis

TitleLot Number
539690

References

Reference overview
Novac, O., et al. 2004. Nucleic Acids Res. 32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-September-2007 JSW
Synonyms3,4,5,6-Tetrabromofluorescein
DescriptionA cell-permeable, xanthenyl compound that prevents mRNA-ribosome interaction and inhibits 5'-mediated/cap-dependent initiation of protein synthesis (>95% inhibition at 50 µM in in vitro translation assays using Krebs, rabbit reticulocyte, or E. coli S30 extract).
FormLight brown solid
Chemical formulaC₂₀H₈Br₄O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or Methanol
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesNovac, O., et al. 2004. Nucleic Acids Res. 32, 902.
Tan, Y.J., et al. 2003. J. Cancer Res. Clin. Oncol. 129, 437.