516481 Sigma-AldrichPepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem
Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin.
More>> Pepstatin A, Synthetic, CAS 26305-03-3, is a reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid
Recommended Products
Overview
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 26305-03-3 | C₃₄H₆₃N₅O₉ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 516481-100MGCN | 塑膠安瓿;塑膠針藥瓶 | 100 mg | |
| 516481-25MGCN | 塑膠安瓿;塑膠針藥瓶 | 25 mg | |
| 516481-5MGCN | 塑膠安瓿;塑膠針藥瓶 | 5 mg |
| Description | |
|---|---|
| Overview | A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437). |
| Effective concentration: 1.0 µM. | |
| Catalogue Number | 516481 |
| Brand Family | Calbiochem® |
| Synonyms | Iva-Val-Val-Sta-Ala-Sta, Isovaleryl-Val-Val-4-amino-3-hydroxy-6-methylheptanoyl-Ala-4-amino-3-hydroxy-6-methylheptanoic Acid |
| Product Information | |
|---|---|
| CAS number | 26305-03-3 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₃₄H₆₃N₅O₉ |
| Chemical formula | C₃₄H₆₃N₅O₉ |
| Optical rotation | Optical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C). |
| Reversible | Y |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | cathepsin D |
| Primary Target IC<sub>50</sub> | EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
| Dimensions |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | SC6155000 |
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| Product Usage Statements |
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| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 516481-100MGCN | 04055977198812 |
| 516481-25MGCN | 07790788055837 |
| 516481-5MGCN | 04055977198836 |
Documentation
Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem MSDS
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Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 516481 |
References
| Reference overview |
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| Isahara, K., et al. 1999. Neuroscience 91, 233. Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun. 251, 204. Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res. 40, 233. Carraway, R.E., et al. 1991. Peptides 12, 107. Eid, M., et al. 1981. Biochem. J. 197, 465. Umezawa, H., et al. 1970. J. Antibiot. 23, 259. |
Brochure
| Title |
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| Western Blotting Tools |
Technical Info
| Title |
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| Protein Blotting Handbook: 6th Edition |