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530050 PRIMA-1 - CAS 5608-24-2 - Calbiochem

A cell-permeable quinuclidinone analog with antitumor properties.

PRIMA-1 - CAS 5608-24-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis

Primary Target: Restores biochemical and biological function to mutant p53
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
5608-24-2C₉H₁₅NO₃

Products

Catalogue NumberPackaging Qty/Pack
530050-10MGCN 塑膠安瓿;塑膠針藥瓶 10 mg
Description
OverviewA cell-permeable quinuclidinone analog with antitumor properties. Restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo. Induces apoptosis in breast cancer cells expressing mutant p53.
Catalogue Number530050
Brand Family Calbiochem®
Synonyms2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
References
ReferencesBykov, V.J., et al. 2002. Nat. Med. 8, 282.
Product Information
CAS number5608-24-2
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₉H₁₅NO₃
Chemical formulaC₉H₁₅NO₃
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetRestores biochemical and biological function to mutant p53
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
530050-10MGCN 04055977269345

Documentation

PRIMA-1 - CAS 5608-24-2 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PRIMA-1 - CAS 5608-24-2 - Calbiochem Certificates of Analysis

TitleLot Number
530050

References

Reference overview
Bykov, V.J., et al. 2002. Nat. Med. 8, 282.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Interactive Pathway Calendar
p53 And Related Products
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2011 RFH
Synonyms2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
DescriptionA cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number5608-24-2
Chemical formulaC₉H₁₅NO₃
Structure formulaStructure formula
Purity≥95% by NMR
SolubilityH₂O (2 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBykov, V.J., et al. 2002. Nat. Med. 8, 282.