529598 Sigma-AldrichPP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem
A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3.
More>> A cell-permeable enlarged PP1 analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3. Less<<Synonyms: 3-Iodobenzyl PP1 analog
Recommended Products
Overview
Replacement Information |
---|
Key Spec Table
CAS # | Empirical Formula |
---|---|
1174182-24-1 | C₁₆H₁₈IN₅ |
Products
Catalogue Number | Packaging | Qty/Pack | |
---|---|---|---|
529598-10MGCN | 玻璃瓶 | 10 mg |
Description | |
---|---|
Overview | A cell-permeable enlarged PP1 (Cat. No. 567809) analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50 = 28, 240 and 120 nM, respectively) over wtAkt1/2/3 (IC50 = >10 µM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3βSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5 µM) and rapidly activates T cell receptor signaling. |
Catalogue Number | 529598 |
Brand Family | Calbiochem® |
Synonyms | 3-Iodobenzyl PP1 analog |
References | |
---|---|
References | Schoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59. Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484. |
Product Information | |
---|---|
CAS number | 1174182-24-1 |
Form | White powder |
Hill Formula | C₁₆H₁₈IN₅ |
Chemical formula | C₁₆H₁₈IN₅ |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
---|
Biological Information | |
---|---|
Purity | ≥97% by HPLC |
Physicochemical Information |
---|
Dimensions |
---|
Materials Information |
---|
Toxicological Information |
---|
Safety Information according to GHS |
---|
Safety Information |
---|
Product Usage Statements |
---|
Packaging Information | |
---|---|
Packaged under inert gas | Packaged under inert gas |
Transport Information |
---|
Supplemental Information |
---|
Specifications |
---|
Global Trade Item Number | |
---|---|
Catalogue Number | GTIN |
529598-10MGCN | 04055977269918 |
Documentation
PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem MSDS
Title |
---|
PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem Certificates of Analysis
Title | Lot Number |
---|---|
529598 |
References
Reference overview |
---|
Schoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59. Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484. |