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529598 PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1174182-24-1C₁₆H₁₈IN₅

Products

Catalogue NumberPackaging Qty/Pack
529598-10MGCN 玻璃瓶 10 mg
Description
OverviewA cell-permeable enlarged PP1 (Cat. No. 567809) analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50 = 28, 240 and 120 nM, respectively) over wtAkt1/2/3 (IC50 = >10 µM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3βSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5 µM) and rapidly activates T cell receptor signaling.
Catalogue Number529598
Brand Family Calbiochem®
Synonyms3-Iodobenzyl PP1 analog
References
ReferencesSchoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59.
Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484.
Product Information
CAS number1174182-24-1
FormWhite powder
Hill FormulaC₁₆H₁₈IN₅
Chemical formulaC₁₆H₁₈IN₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
529598-10MGCN 04055977269918

Documentation

PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

PP1 Analog IV, 3-IB-PP1 - CAS 1174182-24-1 - Calbiochem Certificates of Analysis

TitleLot Number
529598

References

Reference overview
Schoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59.
Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-August-2012 JSW
Synonyms3-Iodobenzyl PP1 analog
DescriptionA cell-permeable enlarged PP1 (Cat. No. 567809) analog that acts as a potent, ATP-competitive and reversible inhibitor of asAkt1/2/3 (IC50 = 28, 240 and 120 nM, respectively) over wtAkt1/2/3 (IC50 = >10 µM). Shown to hyperphosphorylate Akt-Ser473 and -Thr308 in HEK293 cells coexpressed with myr-HA-asAkt1 or myr-HA-asAkt1/2/3 with no effect on pGSK-3βSer9 levels and wtAkt expressing cells. Also, specifically blocks the inhibitory function of membrane asCsk with diminished activity towards wtCsk, induces phosphorylation of Lck-Tyr394 and ERK1/2 in primary mouse T cells (EC50 ~0.5 µM) and rapidly activates T cell receptor signaling.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1174182-24-1
Chemical formulaC₁₆H₁₈IN₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (0.5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSchoenborn, J.R., et al. 2011. Sci. Signal. 4, ra59.
Okuzumi, T., et al. 2009. Nat. Chem. Bio. 5, 484.