528100 Sigma-AldrichPI-103 - CAS 371935-74-9 - Calbiochem
A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR.
More>> A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR. Less<<PI-103 - CAS 371935-74-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, PI 3-K Inhibitor V, mTOR Inhibitor V
Recommended Products
Overview
| Replacement Information |
|---|
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 371935-74-9 | C₁₉H₁₆N₄O₃ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 528100-1MGCN | 塑膠安瓿;塑膠針藥瓶 | 1 mg | |
| 528100-5MGCN | 塑膠安瓿;塑膠針藥瓶 | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110α, p110β, p110δ, p110γ, PI3-KC2β, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. A 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528101) in DMSO is also available. |
| Catalogue Number | 528100 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(4-(4-Morpholinyl)pyrido[3ʹ,2ʹ:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, PI 3-K Inhibitor V, mTOR Inhibitor V |
| References | |
|---|---|
| References | Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840. Fan, Q.W., et al. 2006. Cancer Cell 9, 341. Knight, Z.A., et al. 2006. Cell 125, 733. |
| Product Information | |
|---|---|
| CAS number | 371935-74-9 |
| ATP Competitive | Y |
| Form | White solid |
| Hill Formula | C₁₉H₁₆N₄O₃ |
| Chemical formula | C₁₉H₁₆N₄O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 528100-1MGCN | 04055977270457 |
| 528100-5MGCN | 04055977270464 |
Documentation
PI-103 - CAS 371935-74-9 - Calbiochem MSDS
| Title |
|---|
PI-103 - CAS 371935-74-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
|---|---|
| 528100 |
References
| Reference overview |
|---|
| Raynaud, F.I., et al. 2007. Cancer Res. 67, 5840. Fan, Q.W., et al. 2006. Cancer Cell 9, 341. Knight, Z.A., et al. 2006. Cell 125, 733. |
Posters
| Title |
|---|
| Human Kinome & InhibitorSelect™ Libraries |