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480066 Necrostatin-1, Inactive Control - CAS 64419-92-7 - Calbiochem

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
64419-92-7C₁₂H₁₁N₃OS

Products

Catalogue NumberPackaging Qty/Pack
480066-5MGCN 塑膠安瓿;塑膠針藥瓶 5 mg
Description
OverviewA cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.

Note: This inactive inhibitor of necrosis should not be used in high concentration.
Catalogue Number480066
Brand Family Calbiochem®
Synonyms5-(Indol-3-ylmethyl)-2-thiohydantoin, Nec-1i
References
ReferencesTakahashi et al. 2012. Cell Death and Disease 3, e437.
Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
Product Information
CAS number64419-92-7
ATP CompetitiveN
FormLight yellow crystalline solid
Hill FormulaC₁₂H₁₁N₃OS
Chemical formulaC₁₂H₁₁N₃OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationNecrostatin-1, Inactive Control, CAS 64419-92-7, is a cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) without anti-necroptotic properties.
Biological Information
Primary TargetInactive control for Nec-1 (Cat. No. 480065)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
480066-5MGCN 04055977201888

Documentation

Necrostatin-1, Inactive Control - CAS 64419-92-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Necrostatin-1, Inactive Control - CAS 64419-92-7 - Calbiochem Certificates of Analysis

TitleLot Number
480066

References

Reference overview
Takahashi et al. 2012. Cell Death and Disease 3, e437.
Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-January-2015 JSW
Synonyms5-(Indol-3-ylmethyl)-2-thiohydantoin, Nec-1i
DescriptionA cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.

Note: This inactive inhibitor of necrosis should not be used in high concentration.
FormLight yellow crystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number64419-92-7
Chemical formulaC₁₂H₁₁N₃OS
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTakahashi et al. 2012. Cell Death and Disease 3, e437.
Degterev, A., et al. 2005. Nat. Chem. Biol. 1, 112.