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481480 NF-κB SN50, Cell-Permeable Inhibitor Peptide - Calbiochem

NF-κB SN50, CAS 213546-43-3, is a cell-permeable peptide that contains the NLS sequence of NF-κB p50 linked to the hydrophobic region of K-FGF. Inhibits translocation of the NF-κB into the nucleus.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII

Primary Target: translocation of the NF-κB active complex into the nucleus
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481480
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Overview

Key Spec Table

Empirical Formula
C₁₂₉H₂₃₀N₃₆O₂₉S

Products

Catalogue NumberPackaging Qty/Pack
481480-1MGCN 塑膠安瓿;塑膠針藥瓶 1 mg
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481480-500UGCN 塑膠安瓿;塑膠針藥瓶 500 μg
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Description
OverviewContains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
Catalogue Number481480
Brand Family Calbiochem®
SynonymsAAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
References
ReferencesLin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Product Information
ATP CompetitiveN
DeclarationSold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₂₉H₂₃₀N₃₆O₂₉S
Chemical formulaC₁₂₉H₂₃₀N₃₆O₂₉S
Hygroscopic Hygroscopic
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Biological Information
Primary Targettranslocation of the NF-κB active complex into the nucleus
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide ContentY
Peptide SequenceH-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.
Global Trade Item Number
Catalogue Number GTIN
481480-1MGCN 04055977183771
481480-500UGCN 04055977183788