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FCABS350F Milli-Mark™ Anti-TrkA-FITC Antibody

Detect TrkA using this Milli-Mark Anti-TrkA-FITC Antibody validated for use in FC.

Milli-Mark™ Anti-TrkA-FITC Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors, Neurodegenerative Diseases Gene Symbol: DKFZp781I14186, EC 2.7.10.1, MTC, OTTHUMP00000038736, TRK UniProt Number: P35739
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FCABS350F
100 tests  
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Overview

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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCRbFITCPolyclonal Antibody
Description
Catalogue NumberFCABS350F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™ Anti-TrkA-FITC Antibody
Alternate Names
  • Neurotrophic tyrosine kinase receptor type
  • Oncogene TRK
  • TRK1-transforming tyrosine kinase protein
  • high affinity nerve growth factor receptor
  • neurotrophic tyrosine kinase, receptor, type 1
Background InformationTrkA is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, TrkB, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins. Phosphorylation at Tyr490 is required for Shc association and subsequent activation of the Ras-MAP kinase-signaling cascade, which leads to activation of Elk-1-dependent gene transcription and neurite growth. Phosphorylations at Tyr674 and Tyr675 lie within the catalytic domain of TrkA tyrosine kinase and reflect Trk kinase activity. Additionally, phosphorylation at Tyr751 is required for PI3-kinase association and activation of the Akt signaling cascade.
References
Product Information
FormatFITC
Control
  • HeLa cells
PresentationPurified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationDetect TrkA using this Milli-Mark Anti-TrkA-FITC Antibody validated for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenBacterially expressed purified protein corresponding to the entire extracellular domain of rat TrkA receptor.
EpitopeExtracellular domain
HostRabbit
SpecificityAntibody recognizes TrkA protein.
IsotypeIgG
Species Reactivity
  • Human
Species Reactivity NoteTested and passed on Human. Unconjugated version Cat.No.06-574 is predicted to react with Rat based on immunogen design. The unconjugated part number was also shown to react with Mouse.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • DKFZp781I14186
  • EC 2.7.10.1
  • MTC
  • OTTHUMP00000038736
  • TRK
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryRequired for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway
Molecular WeightTrkA exists as two isoforms: 87 kDa and 88 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using HeLa cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
FCABS350F 04053252754432

Documentation

Milli-Mark™ Anti-TrkA-FITC Antibody MSDS

Title

Safety Data Sheet (SDS) 

Milli-Mark™ Anti-TrkA-FITC Antibody Certificates of Analysis

TitleLot Number
Milli-Mark Anti-TrkA-FITC -
Milli-Mark Anti-TrkA-FITC - 2118982 2118982
Milli-Mark Anti-TrkA-FITC - 2018146 2018146
Milli-Mark Anti-TrkA-FITC - 2023682 2023682
Milli-Mark Anti-TrkA-FITC - 2054818 2054818
Milli-Mark Anti-TrkA-FITC - NRG1920229 NRG1920229
Milli-Mark™ Anti-TrkA-FITC 2480931
Milli-Mark™ Anti-TrkA-FITC - 3166079 3166079
Milli-Mark™ Anti-TrkA-FITC - 3977304 3977304
Milli-Mark™ Anti-TrkA-FITC -2714432 2714432
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