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444605 Melittin - CAS 37231-28-0 - Calbiochem

A 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner.

Melittin - CAS 37231-28-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PKC
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
37231-28-0C₁₃₁H₂₂₉N₃₉O₃₁

Products

Catalogue NumberPackaging Qty/Pack
444605-250UGCN 玻璃瓶 250 μg
Description
OverviewA 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Activates phospholipase A2 and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. Has also been used for affinity purification of several Ca2+-binding proteins.
Catalogue Number444605
Brand Family Calbiochem®
References
ReferencesFukushima, N., et al. 1998. Peptides 19, 811.
Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
Baudier, J., et al. 1987. Biochemistry 26, 2886.
Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.
Product Information
CAS number37231-28-0
ATP CompetitiveN
FormLyophilized
Hill FormulaC₁₃₁H₂₂₉N₃₉O₃₁
Chemical formulaC₁₃₁H₂₂₉N₃₉O₃₁
ReversibleN
Sold on the basis of peptide contentY
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>5-7 µM 5-7 µM for activating phospholipase A2 and inhibits protein kinase C
Purity>97% by HPLC
Physicochemical Information
Cell permeableN
Peptide ContentY
Peptide SequenceH-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSOS3960000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
444605-250UGCN 04055977186130

Documentation

Melittin - CAS 37231-28-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Melittin - CAS 37231-28-0 - Calbiochem Certificates of Analysis

TitleLot Number
444605

References

Reference overview
Fukushima, N., et al. 1998. Peptides 19, 811.
Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
Baudier, J., et al. 1987. Biochemistry 26, 2886.
Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-May-2008 RFH
DescriptionA 26-residue polypeptide from bee venom that binds calmodulin in a Ca2+-dependent manner, activates phospholipase A2, and inhibits protein kinase C (IC50 = 5-7 µM) by binding to the catalytic domain in a Mg2+-ATP sensitive manner. A stimulator of Giα and G11α activity that is reported to inhibit adenylate cyclase activity in synaptic membranes. Has also been used for affinity purification of several Ca2+-binding proteins. Activates Giα-1 and G11α activities and inhibits Gs activity.
FormLyophilized
CAS number37231-28-0
RTECSOS3960000
Chemical formulaC₁₃₁H₂₂₉N₃₉O₃₁
Peptide SequenceH-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH₂
Purity>97% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
Merck USA index14, 5824
ReferencesFukushima, N., et al. 1998. Peptides 19, 811.
Gravitt, K.R. 1994. Biochem. Pharmacol. 47, 425.
Baudier, J., et al. 1987. Biochemistry 26, 2886.
Kincaid, R.L., and Coulson, C.C. 1985. Biochem. Biophys. Res. Commun. 133, 256.