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420107 Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem

420107
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Overview

Key Spec Table

CAS #Empirical Formula
102396-24-7C₃₆H₄₅BrN₄O₆

Products

Catalogue NumberPackaging Qty/Pack
420107-50UGCN 玻璃瓶 50 μg
Description
OverviewA cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca2+ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.
Catalogue Number420107
Brand Family Calbiochem®
References
ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
Product Information
CAS number102396-24-7
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₃₆H₄₅BrN₄O₆
Chemical formulaC₃₆H₄₅BrN₄O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationJasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a cell-permeable F-actin probe. Induces actin polymerization and stabilization. Blocks activation of store-mediated Ca2+ entry into cells.
Biological Information
Primary TargetInducer of actin polymerization and stabilization in vitro
Primary Target IC<sub>50</sub>Kd = 15 nM for actin binding
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
420107-50UGCN 07790788050085