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420107 Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem

Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a cell-permeable F-actin probe. Induces actin polymerization and stabilization. Blocks activation of store-mediated Ca2+ entry into cells.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Inducer of actin polymerization and stabilization in vitro
420107
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
102396-24-7C₃₆H₄₅BrN₄O₆

Products

Catalogue NumberPackaging Qty/Pack
420107-50UGCN 玻璃瓶 50 μg
Description
OverviewA cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca2+ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available.
Catalogue Number420107
Brand Family Calbiochem®
References
ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
Product Information
CAS number102396-24-7
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₃₆H₄₅BrN₄O₆
Chemical formulaC₃₆H₄₅BrN₄O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationJasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a cell-permeable F-actin probe. Induces actin polymerization and stabilization. Blocks activation of store-mediated Ca2+ entry into cells.
Biological Information
Primary TargetInducer of actin polymerization and stabilization in vitro
Primary Target IC<sub>50</sub>Kd = 15 nM for actin binding
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420107-50UGCN 07790788050085

Documentation

Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Jasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem Certificates of Analysis

TitleLot Number
420107

References

Reference overview
Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.

Citations

Title
  • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision24-July-2008 RFH
    DescriptionA cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.
    FormOff-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number102396-24-7
    Chemical formulaC₃₆H₄₅BrN₄O₆
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (10 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up 3 months at -20°C.
    Toxicity Harmful
    ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
    Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
    Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
    Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
    Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
    Citation
  • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
    		•