420107 Sigma-AldrichJasplakinolide, Jaspis johnstoni - CAS 102396-24-7 - Calbiochem
Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a cell-permeable F-actin probe. Induces actin polymerization and stabilization. Blocks activation of store-mediated Ca2+ entry into cells.
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Overview
Key Spec Table
CAS # | Empirical Formula |
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102396-24-7 | C₃₆H₄₅BrN₄O₆ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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420107-50UGCN | 玻璃瓶 | 50 μg |
Description | |
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Overview | A cell-permeable F-actin probe. A cyclodepsipeptide with antifungal and antitumor properties. A potent inducer of actin polymerization and stabilization in vitro. Prevents activation of store-mediated Ca2+ entry into cells. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420127) in DMSO is also available. |
Catalogue Number | 420107 |
Brand Family | Calbiochem® |
Product Information | |
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CAS number | 102396-24-7 |
ATP Competitive | N |
Form | Off-white solid |
Hill Formula | C₃₆H₄₅BrN₄O₆ |
Chemical formula | C₃₆H₄₅BrN₄O₆ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | Inducer of actin polymerization and stabilization in vitro |
Primary Target IC<sub>50</sub> | Kd = 15 nM for actin binding |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Safety Information | |
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R Phrase | R: 20/21/22 Harmful by inhalation, in contact with skin and if swallowed. |
S Phrase | S: 36 Wear suitable protective clothing. |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
420107-50UGCN | 07790788050085 |