Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

420132 JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
1837-91-8C₆H₆Br₆

Products

Catalogue NumberPackaging Qty/Pack
420132-25MGCN 塑膠安瓿;塑膠針藥瓶 25 mg
Description
OverviewA cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
Catalogue Number420132
Brand Family Calbiochem®
Synonyms1,2,3,4,5,6-Hexabromocyclohexane
References
ReferencesSandberg, E.M., et al. 2005. J. Med. Chem. 48, 2526.
Product Information
CAS number1837-91-8
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₆H₆Br₆
Chemical formulaC₆H₆Br₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetJAK2 autophosphorylation
Purity≥ 97% by GC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
420132-25MGCN 04055977188103