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586006 InSolution™ Thapsigargin - CAS 67526-95-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-((Z)-2-methylbut-2-enoyloxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate

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586006
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
586006-2MGCN 玻璃瓶 2 mg
Description
Catalogue Number586006
Brand Family Calbiochem®
Synonyms(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-((Z)-2-methylbut-2-enoyloxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate
References
ReferencesWon, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
Product Information
CAS number67526-95-8
FormLiquid
FormulationA 10 mM (2 mg/307 µL) solution of Thapsigargin (Cat. No. 586005) in DMSO.
Hill FormulaC₃₄H₅₀O₁₂
Chemical formulaC₃₄H₅₀O₁₂
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
586006-2MGCN 04055977265033

Documentation

InSolution™ Thapsigargin - CAS 67526-95-8 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ Thapsigargin - CAS 67526-95-8 - Calbiochem Certificates of Analysis

TitleLot Number
586006

References

Reference overview
Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-August-2013 JSW
Synonyms(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-Acetoxy-4-(butyryloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-((Z)-2-methylbut-2-enoyloxy)-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate
Description cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4 - 13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Activates apoptosis in rat thymocytes and induces apoptosis in human hepatoma cells.Specifically inhibits the fusion of autophagosomes with lysosomes, and induces autophagy.
FormLiquid
FormulationA 10 mM (2 mg/307 µL) solution of Thapsigargin (Cat. No. 586005) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number67526-95-8
Chemical formulaC₃₄H₅₀O₁₂
Structure formulaStructure formula
Purity≥97% by TLC
Storage Protect from light
Avoid freeze/thaw
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity Irritant
ReferencesWon, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399. Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248. Begum, N., et al. 1993. J. Biol. Chem. 268, 3352. Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53. Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969. Wong, W.L., et al. 1993. Biochem. J. 289, 71. Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568. Xu, Y., et al. 1992. J. Neurochem. 59, 2224. Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856. Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.