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365253 InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Go 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole

Primary Target: PKC
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
136194-77-9C₂₄H₁₈N₄O

Products

Catalogue NumberPackaging Qty/Pack
365253-1MLCN 塑膠安瓿;塑膠針藥瓶 1 ml
Description
Catalogue Number365253
Brand Family Calbiochem®
SynonymsGo 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
References
ReferencesGschwendt, M., et al. 1996. FEBS Lett. 392, 77.
Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.
Product Information
CAS number136194-77-9
ATP CompetitiveY
FormLiquid
FormulationA 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.
Hill FormulaC₂₄H₁₈N₄O
Chemical formulaC₂₄H₁₈N₄O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>7.9 nM, 2.3 nM, and 6.2 nM, for rat brain PKC, Ca2+-dependent PKC α-isozyme, and PKCβI, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
365253-1MLCN 04055977192056

Documentation

InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

InSolution™ Gö 6976 - CAS 136194-77-9 - Calbiochem Certificates of Analysis

TitleLot Number
365253

References

Reference overview
Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.

Citations

Title
  • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision02-July-2008 RFH
    SynonymsGo 6976, Solution, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole
    DescriptionInhibitor of protein kinase C (PKC; IC50 = 7.9 nM for rat brain). Selectively inhibits Ca2+-dependent PKCα-isozyme (IC50 = 2.3 nM) and PKCβI (IC50 = 6.2 nM). Does not affect the kinase activity of the Ca2+-independent PKC δ-, ε-, and ζ-isoenzymes even at micromolar levels. A potent antagonist of HIV-1 induction.
    FormLiquid
    FormulationA 500 µg/ml solution of Gö 6976 (Cat. No. 365250) in anhydrous DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    CAS number136194-77-9
    Chemical formulaC₂₄H₁₈N₄O
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Irritant
    ReferencesGschwendt, M., et al. 1996. FEBS Lett. 392, 77.
    Wenzel-Seifert, K., et al. 1994. Biochem. Biophys. Res. Commun. 200, 1536.
    Martiny-Baron, G., et al. 1993. J. Biol. Chem. 268, 9194.
    Qatsha, K.A., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 674.
    Citation
  • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
    		•