400083 Sigma-AldrichHIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem
The HIF-1 Inhibitor, also referenced under CAS 934593-90-5, controls the biological activity of HIF-1.
More>> The HIF-1 Inhibitor, also referenced under CAS 934593-90-5, controls the biological activity of HIF-1. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: CAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 934593-90-5 | C₂₆H₂₉NO₅ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 400083-10MGCN | 玻璃瓶 | 10 mg |
| Description | |
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| Overview | A cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein. Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Also available as a 25 mM solution in DMSO (Cat. No. 400092). |
| Catalogue Number | 400083 |
| Brand Family | Calbiochem® |
| Synonyms | CAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6 |
| References | |
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| References | Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press. Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982. Lee, K., et al. 2007. J. Med. Chem. 50, 1675. |
| Product Information | |
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| CAS number | 934593-90-5 |
| Form | Light beige powder |
| Hill Formula | C₂₆H₂₉NO₅ |
| Chemical formula | C₂₆H₂₉NO₅ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥98% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 400083-10MGCN | 07790788049980 |
Documentation
HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 400083 |
References
| Reference overview |
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| Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press. Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982. Lee, K., et al. 2007. J. Med. Chem. 50, 1675. |