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368020 Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem

Gramicidin A, High Purity, Bacillus brevis, CAS 11029-61-1, is a naturally-occurring ion channel-forming pentadecapeptide. Causes K+/H+ exchange in mitochondria in a non-voltage dependent manner.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: gA

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
11029-61-1C₉₉H₁₄₀N₂₀O₁₇

Products

Catalogue NumberPackaging Qty/Pack
368020-25MGCN 塑膠安瓿;塑膠針藥瓶 25 mg
Description
OverviewNaturally-occurring ion channel-forming pentadecapeptide. The association of two gA peptides causes the formation of a monovalent cation-selective ion channel. Causes K+/H+ exchange in mitochondria in a non-voltage dependent manner. Causes red blood cell lysis at 0.5-1.0 µg/ml.
Catalogue Number368020
Brand Family Calbiochem®
SynonymsgA
References
ReferencesQuigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
Ketchem, R.R., et al. 1993. Science 261, 1457.
Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.
Product Information
CAS number11029-61-1
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₉₉H₁₄₀N₂₀O₁₇
Chemical formulaC₉₉H₁₄₀N₂₀O₁₇
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCauses the formation of a monovalent cation-selective ion channel
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
ContaminantsgC isomers: < 5% by HPLC
Peptide SequenceHCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH₂CH₂OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSMD8230000
Safety Information
R PhraseR: 20/21/22-36/37/38

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing recosntituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
368020-25MGCN 04055977192094

Documentation

Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Gramicidin A, High Purity, Bacillus brevis - CAS 11029-61-1 - Calbiochem Certificates of Analysis

TitleLot Number
368020

References

Reference overview
Quigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
Ketchem, R.R., et al. 1993. Science 261, 1457.
Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-March-2012 JSW
SynonymsgA
DescriptionNaturally occurring, ion channel-forming pentadecapeptide antibiotic that renders membranes permeable to protons and alkali metal ions. Causes red blood cell lysis at concentrations of 0.5-1.0 µg/ml. Gramicidin A causes K+/H+ exchange in mitochondria in a non-voltage dependent manner.
FormWhite to off-white solid
CAS number11029-61-1
RTECSMD8230000
Chemical formulaC₉₉H₁₄₀N₂₀O₁₇
Peptide SequenceHCO-Val-Gly-Ala-D-Leu-Ala-D-Val-Val-D-Val-Trp-D-Leu-Trp-D-Leu-Trp-D-Leu-Trp-NHCH₂CH₂OH
Purity≥90% by HPLC
ContaminantsgC isomers: < 5% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing recosntituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Harmful
Merck USA index14, 4532
ReferencesQuigley, E.P., et al. 2000. J. Membr. Biol. 174, 207.
Koeppe, R.E., et al. 1995. Biochemistry 34, 9299.
Ketchem, R.R., et al. 1993. Science 261, 1457.
Stankovic, C.J., et al. 1990. Anal. Biochem. 184, 100.