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12-533 GSM (GSK3 substrate peptide)

GSM (GSK3 substrate peptide) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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12-533
1 mg  
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Overview

Replacement Information
Description
Catalogue Number12-533
Brand Family Upstate
Trade Name
  • Upstate
DescriptionGSM (GSK3 substrate peptide)
OverviewSynthetic peptide (RRRPASVPPSPSLS RHS(pS)HQRR) based on muscle glycogen synthase 1, where (pS) corresponds to phosphorylated serine.
References
Product Information
Presentation1 mg of GSM lyophilized from 1 mL sterile, distilled water. Lyophilized powder.
Quality LevelMQ100
Applications
Key Applications
  • Kinase Assay
Application NotesKinase Assay: Substrate for GSK3α, active (Catalog # 14-492), GSK3β, active (Catalog # 14-306), GSK3β, active, rat (Catalog # 14-538).
Biological Information
Entrez Gene Number
Entrez Gene SummaryGlycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase (see GYS1, {138570}) and transcription factors (e.g., JUN, {165160}). It also plays a role in the WNT ({164820}) and PI3K (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]
Gene Symbol
  • GSK3A
  • DKFZp686D0638
Protein TargetGSK3
Target Sub-FamilyCMGC
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P49840 # Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).
SIZE: 483 amino acids; 50981 Da
SUBUNIT: Monomer (By similarity).
SIMILARITY: SwissProt: P49840 ## Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. & Contains 1 protein kinase domain.
Molecular WeightMolecular weight: 2673 Daltons.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated as a substrate for GSK3β (Catalog # 14-306).
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsLyophilized: 2 years at -20°C. Rehydrated: 6 months at -20°C
Packaging Information
Material Size1 mg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
12-533 04053252743931

Documentation

GSM (GSK3 substrate peptide) MSDS

Title

Safety Data Sheet (SDS) 

GSM (GSK3 substrate peptide) Certificates of Analysis

TitleLot Number
GSM 3071623
GSM (GSK3 substrate peptide) 3011658
GSM (GSK3 substrate peptide) 3152197
GSM (GSK3 substrate peptide) 2915295
GSM (GSK3 substrate peptide) 2470375
GSM (GSK3 substrate peptide) 3002642
GSM (GSK3 substrate peptide) -
GSM (GSK3 substrate peptide) - 0611045252 0611045252
GSM (GSK3 substrate peptide) - 1350556 1350556
GSM (GSK3 substrate peptide) - 1947720 1947720
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References

Reference overviewApplicationPub Med ID
Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites
Ryves, W. J., et al
Biochem Biophys Res Commun, 290:967-72 (2002)  2002

Kinase Assay11798168 11798168
An assay for glycogen synthase kinase 3 (GSK-3) for use in crude cell extracts
Ryves, W. J., et al
Anal Biochem, 264:124-7 (1998)  1998

Kinase Assay9784196 9784196

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