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48-602MAG
Buffer Detection Kit for Magnetic Beads
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341216
Sigma-AldrichEzrin Inhibitor, NSC668394 - CAS 382605-72-3 - Calbiochem
The Ezrin Inhibitor, NSC668394 controls the biological activity of Ezrin.
More>>The Ezrin Inhibitor, NSC668394 controls the biological activity of Ezrin. Less<<
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
A cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.
Ezrin Inhibitor, NSC668394 - CAS 382605-72-3 - Calbiochem Certificates of Analysis
Title
Lot Number
341216
References
Reference overview
Bulut, G., et al. 2011. Oncogene31, 269.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.
Form
Reddish orange solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
382605-72-3
Chemical formula
C₁₇H₁₂Br₂N₂O₃
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (50 mg/ml; clear, red-orange solution)
Storage
Protect from light
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
