Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

324732 ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem

The ErbB2 Inhibitor II, also referenced under CAS 928207-02-7, controls the biological activity of ErbB2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole

View Products on Sigmaaldrich.com
324732
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
928207-02-7C₁₅H₁₀N₄O

Products

Catalogue NumberPackaging Qty/Pack
324732-5MGCN 塑膠安瓿;塑膠針藥瓶 5 mg
Description
OverviewA cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.
Catalogue Number324732
Brand Family Calbiochem®
Synonyms4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole
References
ReferencesCheng, Z. Y., et al. 2007. Bioorg. Med. Chem. 15, 1533.
Product Information
CAS number928207-02-7
FormYellow solid
Hill FormulaC₁₅H₁₀N₄O
Chemical formulaC₁₅H₁₀N₄O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324732-5MGCN 04055977216028

Documentation

ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

ErbB2 Inhibitor II - CAS 928207-02-7 - Calbiochem Certificates of Analysis

TitleLot Number
324732

References

Reference overview
Cheng, Z. Y., et al. 2007. Bioorg. Med. Chem. 15, 1533.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-April-2011 RFH
Synonyms4-(3-Phenoxyphenyl)-5-cyano-2H-1,2,3-triazole
DescriptionA cell-permeable triazole compound that targets the ATP-binding site of erbB2/HER2 and reduces the phosphorylation of erbB2 in MDA-MB-453 cells (IC50 = 6.6 µM), but not that of the overexpressed erbB1 in MDA-MB-468 cells even at concentrations as high as 100 µM. Shown to suppress MDA-MB-453 growth with an IC50 of 30.9 µM.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number928207-02-7
Chemical formulaC₁₅H₁₀N₄O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesCheng, Z. Y., et al. 2007. Bioorg. Med. Chem. 15, 1533.