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324875 Eicosapentaenoic Acid - CAS 10417-94-4 - Calbiochem

Cell permeable. Shown to have a beneficial effect in cardiovascular diseases and inflammation. Inhibits 5-lipoxygenase and reduces thromboxane A₂ production and blood viscosity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: EPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3

Primary Target: 5-lipoxygenase
324875
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
10417-94-4C₂₀H₃₀O₂

Products

Catalogue NumberPackaging Qty/Pack
324875-25MGCN 玻璃瓶 25 mg
Description
OverviewCell permeable. Shown to have a beneficial effect in cardiovascular diseases and inflammation. Causes elevation of intracellular free Ca2+. Inhibits 5-lipoxygenase and reduces thromboxane A2 production and blood viscosity. Reported to induce apoptosis in pancreatic cancer cell lines and to inhibit liver metastasis.
Catalogue Number324875
Brand Family Calbiochem®
SynonymsEPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3
References
ReferencesIwamoto, S., et al. 1998. Nutr. Cancer 31, 143.
Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375.
Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830.
Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166.
James, M.J., et al. 1993. J. Exp. Med. 178, 2261.
chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19.
Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.
Product Information
CAS number10417-94-4
ATP CompetitiveN
FormClear liquid
Hill FormulaC₂₀H₃₀O₂
Chemical formulaC₂₀H₃₀O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target5-lipoxygenase
Purity≥99% by GC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSJX3820000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324875-25MGCN 04055977215847

Documentation

Eicosapentaenoic Acid - CAS 10417-94-4 - Calbiochem Certificates of Analysis

TitleLot Number
324875

References

Reference overview
Iwamoto, S., et al. 1998. Nutr. Cancer 31, 143.
Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375.
Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830.
Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166.
James, M.J., et al. 1993. J. Exp. Med. 178, 2261.
chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19.
Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-May-2008 RFH
SynonymsEPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3
DescriptionFatty acid isolated from microscopic algae. Serves as a precursor for the prostaglandin-3 and thromboxane-3 families. It differs from arachidonic acid by the extra double bond between C17 and C18. Has a beneficial effect in cardiovascular diseases and inflammation. Also acts as an antihyperlipoproteinenic agent. Causes elevations of intracellular free Ca2+. Inhibits 5-lipoxygenase and reduces thromboxane A2 production and blood viscosity.
FormClear liquid
Intert gas (Yes/No) Packaged under inert gas
CAS number10417-94-4
RTECSJX3820000
Chemical formulaC₂₀H₃₀O₂
Structure formulaStructure formula
Purity≥99% by GC
SolubilityMethanol (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
Merck USA index14, 3531
ReferencesIwamoto, S., et al. 1998. Nutr. Cancer 31, 143.
Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375.
Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830.
Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166.
James, M.J., et al. 1993. J. Exp. Med. 178, 2261.
chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19.
Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.