324623 Sigma-AldrichEg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem
The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 909250-29-9 | C₁₄H₁₁FN₂OS |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 324623-5MGCN | 玻璃瓶 | 5 mg |
| Description | |
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| Overview | A cell-permeable Monastrol (Cat. No. 475879) analog with much enhanced potency and selectivity (over 8 other kinesins) in inhibiting mitotic kinesin Eg5-ATPase activity (IC50 = 1.17 vs. 20.73 µM for VS-83 and Monastrol, respectively) and in inducing monoasters formation (EC50 = 7.27 vs. 58.74 µM for BSC-1 cells treated with VS-83 and Monastrol, respectively). Shown to exhibit ≥10-fold antiproliferative activity than Monastrol against U-87 MG, U-118 MG, and U-373 MG glioblastoma cells. |
| Catalogue Number | 324623 |
| Brand Family | Calbiochem® |
| Synonyms | 5-Fluoro-3,4-dihydro-4(3ʹ-hydroxyphenyl)quinazoline-2(1H)-thione |
| References | |
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| References | Muller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157. Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024. Sarli, V., et al. 2005. ChemBioChem 6, 2005. |
| Product Information | |
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| CAS number | 909250-29-9 |
| Form | White solid |
| Hill Formula | C₁₄H₁₁FN₂OS |
| Chemical formula | C₁₄H₁₁FN₂OS |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥99% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 324623-5MGCN | 04055977197389 |
Documentation
Eg5 Inhibitor IV, VS-83 - CAS 909250-29-9 - Calbiochem MSDS
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References
| Reference overview |
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| Muller, C., et al. 2007. Cancer Chemother. Pharmacol. 59, 157. Santamaria, A., et al. 2007. Mol. Biol. Cell 18, 4024. Sarli, V., et al. 2005. ChemBioChem 6, 2005. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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