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324483 Ebselen - CAS 60940-34-3 - Calbiochem

A cell-permeable, non-selective inhibitor of COX-1 and COX-2.

Ebselen - CAS 60940-34-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51

Primary Target: COX-1, COX-2
324483
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
60940-34-3C₁₃H₉NOSe

Products

Catalogue NumberPackaging Qty/Pack
324483-5MGCN 玻璃瓶 5 mg
Description
OverviewA cell-permeable, non-selective inhibitor of COX-1 and COX-2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent active against acute focal ischemic injury. Inhibits LPS-induced NF-κB nuclear translocation and LPS-induced phosphorylation of JNK.
Catalogue Number324483
Brand Family Calbiochem®
Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
References
ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.
Product Information
CAS number60940-34-3
ATP CompetitiveN
FormLyophilized solid
Hill FormulaC₁₃H₉NOSe
Chemical formulaC₁₃H₉NOSe
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1, COX-2
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324483-5MGCN 04055977197242

Documentation

Ebselen - CAS 60940-34-3 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Ebselen - CAS 60940-34-3 - Calbiochem Certificates of Analysis

TitleLot Number
324483

References

Reference overview
Shimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2008 RFH
Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
DescriptionNon-selective, cell-permeable, inhibitor of the cyclooxygenase activity of prostaglandin H synthase 1 and 2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent against acute focal ischemic injury.
FormLyophilized solid
CAS number60940-34-3
Chemical formulaC₁₃H₉NOSe
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (5 mg/ml) or Ethanol
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.