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310500 D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III

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310500
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
119567-63-4C₂₀H₄₁NO₂

Products

Catalogue NumberPackaging Qty/Pack
310500-5MGCN 塑膠安瓿;塑膠針藥瓶 5 mg
Description
OverviewA cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
Catalogue Number310500
Brand Family Calbiochem®
SynonymsDMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
References
ReferencesCuvillier, O., et al. 1996. Nature 381, 800.
Ohta, H., et al. 1995. Cancer Res. 55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
Hanada, K., et al. 1991. Biochemistry 30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.
Product Information
CAS number119567-63-4
ATP CompetitiveN
FormWaxy solid/Clear oil
Hill FormulaC₂₀H₄₁NO₂
Chemical formulaC₂₀H₄₁NO₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>12 µM against PKC
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
310500-5MGCN 04055977216837

Documentation

D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem Certificates of Analysis

TitleLot Number
310500

References

Reference overview
Cuvillier, O., et al. 1996. Nature 381, 800.
Ohta, H., et al. 1995. Cancer Res. 55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
Hanada, K., et al. 1991. Biochemistry 30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.

Brochure

Title
Bioactive Lipids Technical Bulletin
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2010 RFH
SynonymsDMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
DescriptionA cell-permeable and reversible inhibitor of protein kinase C (IC50 = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.
FormWaxy solid/Clear oil
CAS number119567-63-4
Chemical formulaC₂₀H₄₁NO₂
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (5 mg/ml), Ethanol, or Methanol
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity Irritant
ReferencesCuvillier, O., et al. 1996. Nature 381, 800.
Ohta, H., et al. 1995. Cancer Res. 55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
Hanada, K., et al. 1991. Biochemistry 30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.