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250255 Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem

Cytochalasin D, Zygosporium mansonii, CAS 22144-77-0, is a fungal toxin that is about 10-fold more potent than cytochalasin B in inhibiting actin filament function. Blocks cytoplasmic division.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Actin filament function
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250255
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
22144-77-0C₃₀H₃₇NO₆

Products

Catalogue NumberPackaging Qty/Pack
250255-1MGCN 玻璃瓶 1 mg
Description
OverviewCell-permeable fungal toxin. About 10-fold more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inactivates low conductance K+ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca2+ levels. Exhibits antitumor activity. Also available as a 10 mM solution in DMSO (Cat. No. 504776).
Catalogue Number250255
Brand Family Calbiochem®
References
ReferencesSasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
Product Information
CAS number22144-77-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₀H₃₇NO₆
Chemical formulaC₃₀H₃₇NO₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetActin filament function
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSGZ4850000
Safety Information
R PhraseR: 26/27/28-61

Very toxic by inhalation, in contact with skin and if swallowed.
May cause harm to the unborn child.
S PhraseS: 3/7/9-22-36/37/39-45

Keep container tightly closed, in a cool well ventilated place.
Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in chloroform, aliquot, dry under a stream of nitrogen, and freeze (-20°C). Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
250255-1MGCN 07790788048952

Documentation

Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem Certificates of Analysis

TitleLot Number
250255

References

Reference overview
Sasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.

Citations

Title
  • Jessica A. Gorski, et al. (2005) Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Molecular Biology of the Cell 16, 3574-3590.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision29-April-2008 RFH
    DescriptionA cell-permeable fungal toxin that is approximately 10 times more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments at 10 µM. Inactivates low conductance K+ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca2+ levels. Cytochalasin D also exhibits antibiotic and anti-tumor activity.
    FormWhite solid
    CAS number22144-77-0
    RTECSGZ4850000
    Chemical formulaC₃₀H₃₇NO₆
    Structure formulaStructure formula
    Purity≥98% by TLC
    SolubilityDMSO (2 mg/ml) or Chloroform (2 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution in chloroform, aliquot, dry under a stream of nitrogen, and freeze (-20°C). Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 3 months at -20°C.
    Toxicity Highly Toxic & Carcinogenic / Teratogenic
    Merck USA index14, 2790
    ReferencesSasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
    Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
    Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
    Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
    Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
    Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
    Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
    Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.
    Citation
  • Jessica A. Gorski, et al. (2005) Association of an A-kinase-anchoring protein signaling scaffold with cadherin adhesion molecules in neurons and epithelial cells. Molecular Biology of the Cell 16, 3574-3590.
    		•