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219401
Sigma-AldrichCathepsin D, Human Liver
Cathepsin D, Human Liver, CAS 9025-26-7, is a purified native cathepsin D from human liver. Overexpression of cathepsin D in is associated with higher risk of cancer relapse and metastasis.
More>>Cathepsin D, Human Liver, CAS 9025-26-7, is a purified native cathepsin D from human liver. Overexpression of cathepsin D in is associated with higher risk of cancer relapse and metastasis. Less<<
Cathepsin D, Human Liver MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Native cathepsin D from human liver. A major lysosomal aspartyl protease produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix.
Catalogue Number
219401
Brand Family
Calbiochem®
References
References
Berchem, G., et al. 2002. Oncogene21, 5951. Barbi, G.P., et al. 1994. Oncology51, 329. Krishnan, V., et al. 1994. J. Biol. Chem.269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem.266, 23586. Johnson, G.V., et al. 1991. J. Neurochem.57, 1577. Erickson, A. 1989. J. Cell. Biochem.40, 31.
Product Information
CAS number
9025-26-7
Unit of Definition
One unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
EC number
3.4.23.5
Form
Lyophilized
Formulation
Lyophilized from 2 mM sodium phosphate buffer, pH 6.5.
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity
≥300 units/mg protein
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Standard Handling
Storage
-20°C
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
Global Trade Item Number
Catalogue Number
GTIN
219401-15UCN
04055977201710
219401-30UCN
04055977201727
Documentation
Cathepsin D, Human Liver Certificates of Analysis
Title
Lot Number
219401
References
Reference overview
Berchem, G., et al. 2002. Oncogene21, 5951. Barbi, G.P., et al. 1994. Oncology51, 329. Krishnan, V., et al. 1994. J. Biol. Chem.269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem.266, 23586. Johnson, G.V., et al. 1991. J. Neurochem.57, 1577. Erickson, A. 1989. J. Cell. Biochem.40, 31.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
28-April-2008 RFH
Description
Native cathepsin D from human liver. Degrades the extracellular matrix and releases growth factors bound to the matrix. Overexpression of cathepsin D in human breast cancers is associated with a higher risk of relapse and metastasis.
Form
Lyophilized
Formulation
Lyophilized from 2 mM sodium phosphate buffer, pH 6.5.
Source
Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number
9025-26-7
EC number
3.4.23.5
Purity
≥90% by SDS-PAGE
Specific activity
≥300 units/mg protein
Unit definition
One unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
Solubility
Sterile H₂O or aqueous buffers. Please see vial label for lot-specific reconstitution volume.
Storage
-20°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
Toxicity
Standard Handling
Merck USA index
14, 1905
References
Berchem, G., et al. 2002. Oncogene21, 5951. Barbi, G.P., et al. 1994. Oncology51, 329. Krishnan, V., et al. 1994. J. Biol. Chem.269, 15912. Touitou, I., et al. 1994. Eur. J. Cancer30A, 390. Rijnboutt, S., et al. 1991. J. Biol. Chem.266, 23586. Johnson, G.V., et al. 1991. J. Neurochem.57, 1577. Erickson, A. 1989. J. Cell. Biochem.40, 31.
