218719 Sigma-AldrichCasein Kinase I Inhibitor III, PF-4800567 - CAS 1188296-52-7 - Calbiochem
The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The Casein Kinase I Inhibitor III, PF-4800567 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 1188296-52-7 | C₁₇H₁₈ClN₅O₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 218719-5MGCN | 玻璃瓶 | 5 mg |
| Description | |
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| Overview | A cell-permeable pyrazolopyrimidinylamino compound that acts as a potent, ATP-competitive and reversible inhibitor of CKIε with ~22-fold greater potency over CKIδ (IC50 = 32 and 711 nM, respectively) and displays excellent selectivity among 50-kinases, with the only exception of EGFR (69% inhibition at 1 µM). Shown to preferentially block PER3 (PERIOD3) nuclear translocation in COS7-GFP-PER3-CKIε cells over CKIδ-transfected cells (IC50 = 0.13 and 2.65 µM, respectively), and PER2 degradation in COS7-GFP-PER2-CKIε cells. Unlike Casein Kinase I Inhibitor II, PF-670462 (Cat. No. 218716), PF-4800567 exerts only marginal effect on circadian clock under similar conditions. |
| Catalogue Number | 218719 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(3-Chlorophenoxymethyl)-1-(tetrahydropyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine, HCl, CKI Inhibitor III, PF-4800567 |
| Product Information | |
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| CAS number | 1188296-52-7 |
| Form | Beige solid |
| Hill Formula | C₁₇H₁₈ClN₅O₂ |
| Chemical formula | C₁₇H₁₈ClN₅O₂ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥99% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 218719-5MGCN | 04055977218947 |
Documentation
Casein Kinase I Inhibitor III, PF-4800567 - CAS 1188296-52-7 - Calbiochem MSDS
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Casein Kinase I Inhibitor III, PF-4800567 - CAS 1188296-52-7 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 218719 |
References
| Reference overview |
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| Meng, Q.J., et al. 2010. Proc. Natl. Acad. Sci. USA 24, 15240. Etchegaray, J.P., et al. 2010. PLoS One 5, e10303. Walton, K.M., et al. 2009. J. Pharmacol. Exp. Ther. 330, 430. Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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