205531 Sigma-AldrichCA-074 Me - Calbiochem
CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.
More>> CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B. Less<<Synonyms: Cathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
Recommended Products
Overview
Replacement Information |
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Key Spec Table
Empirical Formula |
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C₁₉H₃₁N₃O₆ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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205531-1MGCN | 塑膠安瓿;塑膠針藥瓶 | 1 mg |
Description | |
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Overview | A cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro. |
Catalogue Number | 205531 |
Brand Family | Calbiochem® |
Synonyms | Cathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester |
Product Information | |
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ATP Competitive | N |
Form | White solid |
Hill Formula | C₁₉H₃₁N₃O₆ |
Chemical formula | C₁₉H₃₁N₃O₆ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | cathepsin B |
Primary Target IC<sub>50</sub> | 2.24 nM against cathepsin B |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Dimensions |
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Materials Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information |
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Transport Information |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
205531-1MGCN | 07790788048433 |
Documentation
CA-074 Me - Calbiochem MSDS
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CA-074 Me - Calbiochem Certificates of Analysis
Title | Lot Number |
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205531 |
References
Reference overview |
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Sever, N., et al. 2002. Biol. Chem. 383, 839. Authier, F., et al. 1999. J. Biol. Chem. 274, 33723. Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118. Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377. |
Citations
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Data Sheet | ||||||||||||||||||||||||||||
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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