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189480 Autocamtide-2 Related Inhibitory Peptide - Calbiochem

The Autocamtide-2 Related Inhibitory Peptide controls the biological activity of calmodulin-dependent protein kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL

Primary Target: Cam Kinase-2
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189480
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₆₄H₁₁₆N₂₂O₁₉

Products

Catalogue NumberPackaging Qty/Pack
189480-500UGCN 塑膠安瓿;塑膠針藥瓶 500 μg
Description
OverviewNon-phosphorylatable analog of Autocamtide-2 (Cat. No. 189475) that acts as a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM). It is about 50 times more potent than [Ala286]-CaM kinase II Inhibitor, 281-301 (Cat. No. 208710). Has no effect on PKA, PKC, and CaM kinase IV. Blocks Ca2+-induced insulin secretion from electropermeabilized islets.
Catalogue Number189480
Brand Family Calbiochem®
SynonymsAIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
References
ReferencesBhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.
Product Information
ATP CompetitiveN
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₆₄H₁₁₆N₂₂O₁₉
Chemical formulaC₆₄H₁₁₆N₂₂O₁₉
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetCam Kinase-2
Primary Target IC<sub>50</sub>40 nM against calmodulin-dependent protein kinase II
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
189480-500UGCN 04055977221770

Documentation

Autocamtide-2 Related Inhibitory Peptide - Calbiochem MSDS

Title

Safety Data Sheet (SDS) 

Autocamtide-2 Related Inhibitory Peptide - Calbiochem Certificates of Analysis

TitleLot Number
189480

References

Reference overview
Bhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-April-2008 RFH
SynonymsAIP, (Ala⁹)-Autocamtide-2, KKALRRQEAVDAL
DescriptionNon-phosphorylatable analog of Autocamptide-2 (Cat. No. 189475) that is a highly specific and potent inhibitor of calmodulin-dependent protein kinase II (IC50 = 40 nM) and is 50 and 500 times more potent than Ala286-CaM kinase II inhibitor, 281-301 (Cat. No. 208710) and KN-93 (Cat. No. 422708), respectively. Has no effect of PKA, PKC, and CaM kinase IV.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Chemical formulaC₆₄H₁₁₆N₂₂O₁₉
Peptide SequenceH-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
Purity≥97% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBhat, H.S., et al. 2000. Biochem. Pharmacol. 60, 1655.
Ishida, A., et al. 1995. Biochem. Biophys. Res. Commun. 212, 806.