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MAB2511Z Anti-VCAM-1 Antibody, clone P8B1, Azide Free

Anti-VCAM-1 Antibody, clone P8B1, Azide Free is an antibody against VCAM-1.

Anti-VCAM-1 Antibody, clone P8B1, Azide Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Adhesion (CAMs) Gene Symbol: VCAM1, INCAM-100, MGC99561, CD106, DKFZp779G2333, L1CAM UniProt Number: P19320
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MAB2511Z
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFUNCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB2511Z
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-VCAM-1 Antibody, clone P8B1, Azide Free
Alternate Names
  • CD106
  • MAB2511
References
Product Information
FormatPurified
PresentationLiquid in 0.2 M phosphate buffer to 0.25 M NaCl, pH 7.6, containing no preservatives.
Quality LevelMQ100
Applications
ApplicationAnti-VCAM-1 Antibody, clone P8B1, Azide Free is an antibody against VCAM-1.
Key Applications
  • Affects Function
Application NotesFunction blocking

Optimal working dilutions must be determined by end user.
Biological Information
CloneP8B1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityMAB2511Z recognizes the human VCAM-1 molecule. The antibody inhibits VLA-4 (integrin alpha4beta1) binding and recognizes a different epitope than that which is recognized by MAB2144 (P3C4 clone).
IsotypeIgG2b
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Gene Symbol
  • VCAM1
  • INCAM-100
  • MGC99561
  • CD106
  • DKFZp779G2333
  • L1CAM
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P19320 # Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
SIZE: 739 amino acids; 81276 Da
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
DOMAIN: SwissProt: P19320 Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
PTM: Sialoglycoprotein.
DISEASE:SwissProt: P19320 # May play an important role in the genesis of atherosclerosis and rheumatoid arthritis.
SIMILARITY: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB2511Z 04053252664861

Documentation

Anti-VCAM-1 Antibody, clone P8B1, Azide Free MSDS

Title

Safety Data Sheet (SDS) 

Anti-VCAM-1 Antibody, clone P8B1, Azide Free Certificates of Analysis

TitleLot Number
MOUSE ANTI HUMAN VCAM-1 PRESERVATIVE-FREE MONOCLONAL ANTIBODY - 2463664 2463664
MOUSE ANTI HUMAN VCAM-1 - 3847529 3847529
MOUSE ANTI HUMAN VCAM-1 PRESERVATIVE-FREE MONOCLONAL ANTIBODY 2932434
MOUSE ANTI HUMAN VCAM-1 PRESERVATIVE-FREE MONOCLONAL ANTIBODY 2903960
MOUSE ANTI HUMAN VCAM-1 PRESERVATIVE-FREE MONOCLONAL ANTIBODY - 2015560 2015560
MOUSE ANTI HUMAN VCAM-1 PRESERVATIVE-FREE MONOCLONAL ANTIBODY -2857192 2857192