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MAB4343-25UG Anti-Sox-2 (Mouse Monoclonal)

Anti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB.

Anti-Sox-2 (Mouse Monoclonal) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: SOX2, ANOP3, MGC2413, MCOPS3 UniProt Number: P48431
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MAB4343-25UG
25 μg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MICC, IHC, WBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB4343-25UG
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Sox-2 (Mouse Monoclonal)
Background InformationSox-2 plays a key role in embryonic stem cell development, and has been shown to help stem cells maintain pluripotent potential. It has also been shown to be associated with uncommitted dividing stem cell and precursor cells of the developing CNS.
References
Product Information
FormatPurified
PresentationPurified Immunoglobulin by protein A affinity chromatography and presented as a liquid in 0.02 M phosphate buffer, pH 7.6, with 0.25 M NaCl. Contains 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-SOX-2 Antibody detects level of SOX-2 & has been published & validated for use in IC, IH & WB.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
  • Western Blotting
Biological Information
ImmunogenRecombinant GST Fusion protein.
Clone6F1.2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG2b
Species Reactivity
  • Human
  • Mouse
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
Gene Symbol
  • SOX2
  • ANOP3
  • MGC2413
  • MCOPS3
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P48431 # Can form ternary complexes with OCT-1 or OCT-3 but acts as a transcriptional activator of FGF-4 enhancer DNA sequences only in conjunction with OCT-3 (By similarity).
SIZE: 317 amino acids; 34310 Da
SUBCELLULAR LOCATION: Nucleus.
DISEASE: SwissProt: P48431 # Defects in SOX2 are the cause of microphthalmia syndromic type 3 (MCOPS3) [MIM:206900]. MCOPS3 is characterized by the association of microphthalmia or clinical anophthalmia with anomalies such as microcephaly, short stature, hypogonadotropic hypogonadism, esophageal atresia and neurologic manifestations.
SIMILARITY: SwissProt: P48431 ## Contains 1 HMG box DNA-binding domain.
Stem Cell Type
  • Human Embryonic Stem Cells
  • Mouse Embryonic Stem Cells
  • Neural Stem Cells
  • Induced Pluripotent Stem Cells
Molecular Weight~34 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceTested
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB4343-25UG 04054839342721