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AB5852 Anti-SHANK1a Antibody, NT

Anti-SHANK1a Antibody, N-terminus is an antibody against SHANK1a for use in WB.

Anti-SHANK1a Antibody, NT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Synapse & Synaptic Biology Gene Symbol: SHANK1, SSTRIP, SPANK-1, Shank1, synamon UniProt Number: Q9Y566
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AB5852
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
RWBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB5852
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-SHANK1a Antibody, NT
Background InformationShank is a novel family of postsynaptic density proteins (PSD) that bind to PDS-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the actin cytoskeleton. Shank1a is a splice variant of Shank1.
References
Product Information
FormatPurified
PresentationPurified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-SHANK1a Antibody, N-terminus is an antibody against SHANK1a for use in WB.
Key Applications
  • Western Blotting
Application NotesWestern blotting: 1:500-1:1,000

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenSynthetic peptide corresponding to the N-terminus of rat Shank1a.
EpitopeN-terminus
HostRabbit
SpecificityRecognizes Shank1a, N-terminal.
Species Reactivity
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SHANK1
  • SSTRIP
  • SPANK-1
  • Shank1
  • synamon
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9Y566 # Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
SIZE: 2161 amino acids; 225021 Da
SUBUNIT: May homomultimerize via its SAM domain (By similarity). Interacts with the C-terminus of SSTR2 via the PDZ domain. Interacts with IGSF9, SHARPIN, SPTAN1, HOMER1 and DLGAP1/GKAP isoforms 1 and 2 (By similarity). Part of a complex with DLG4/PSD- 95 and DLGAP1/GKAP (By similarity). Interacts with BAIAP2.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells (By similarity).TISSUE SPECIFICITY: Expressed in brain particularly in the amygdala, hippocampus, substantia nigra and thalamus. Isoform 2 seems to be expressed ubiquitously.
SIMILARITY: SwissProt: Q9Y566 ## Belongs to the SHANK family. & Contains 6 ANK repeats. & Contains 1 PDZ (DHR) domain. & Contains 1 SAM (sterile alpha motif) domain. & Contains 1 SH3 domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB5852 04053252279966