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AB10418 Anti-Puma BH3 domain Antibody

Anti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.

Anti-Puma BH3 domain Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: JFY-1, JFY1 , PUMA UniProt Number: Q9BXH1
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AB10418
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWBRbPurifiedPolyclonal Antibody
Description
Catalogue NumberAB10418
DescriptionAnti-Puma BH3 domain Antibody
Alternate Names
  • BCL2 binding component 3
  • Bcl-2 binding component 3
  • p53 up-regulated modulator of apoptosis
Background InformationPUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis
References
Product Information
FormatPurified
Control
  • Western Blot : Mouse brain lysate
PresentationPurified in PBS with 0.09% NaN3.
Quality LevelMQ100
Applications
ApplicationAnti-Puma BH3 domain Antibody is an antibody against Puma BH3 domain for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenThis antibody was developed against a synthetic peptide selected from the C-terminal region of human Puma.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThe antibody reacts with the 21 kDa Puma BH3 domain protein.
Species Reactivity
  • Mouse
Species Reactivity NoteReacts with mouse. Other species have not been tested.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • JFY-1
  • JFY1
  • PUMA
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: Essential mediator of p53-dependent and p53-independent apoptosis.
SUBUNIT STRUCTURE: Interacts with MCL1 and BCL2A1 By similarity. Interacts with BCL2 and BCL2L1/BCL-XL.
SUBCELLULAR LOCATION: Mitochondrion. Note= Localized to the mitochondria in order to induce cytochrome c release.
TISSUE SPECIFICTY: Ubiquitously expressed.
INDUCTION: By DNA damage, glucocorticoid treatment, growth factor deprivation and p53.
SEQUENCE SIMILARITIES: Belongs to the Bcl-2 family.
Molecular Weight21 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceWestern Blot Analysis: 1:250 dilution of this antibody detected Puma BH3 domain on mouse brain lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at 2-8°C for 6 months from date of receipt. For long term storage, store at -20°C
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB10418 04053252401305

Documentation

Anti-Puma BH3 domain Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-Puma BH3 domain Antibody Certificates of Analysis

TitleLot Number
Anti-Puma BH3 domain - 2438261 2438261
Anti-Puma BH3 domain - 2466925 2466925
Anti-Puma BH3 domain - 2469327 2469327
Anti-Puma BH3 domain - 2327075 2327075
Anti-Puma BH3 domain - 2492238 2492238
Anti-Puma BH3 domain - 3583838 3583838
Anti-Puma BH3 domain - NG1594524 NG1594524
Anti-Puma BH3 domain - NG1873195 NG1873195
Anti-Puma BH3 domain -2670357 2670357
Anti-Puma BH3 domain -2851279 2851279
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