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05-1417 Anti-PTP-PEST Antibody, clone AG25

Anti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.

Anti-PTP-PEST Antibody, clone AG25 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PTPN12, PTPG1, PTP-PEST, EC 3.1.3.48 UniProt Number: Q05209
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05-1417
100 µL  
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Overview

Replacement Information
Replacement Information05-1417 is a recommended replacement for MAB3739

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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, IP, ICCMAscitesMonoclonal Antibody
Description
Catalogue Number05-1417
ReplacesMAB3739
DescriptionAnti-PTP-PEST Antibody, clone AG25
Alternate Names
  • Protein-tyrosine phosphatase G1
  • Tyrosine-protein phosphatase non-receptor type12
  • Protein tyrosine phosphatase, non-receptor type 12
Background InformationThe protein tyrosine phosphatase PTP-PEST is an cytosolic protein tyrosine phosphatase that is ubiquitously expressed in mammalian tissues. PTP-PEST associates with multiple cytoskeleton and cell adhesion molecules suggesting a regulatory role in controlling cell shape and motility.
References
Product Information
FormatAscites
Control
  • HeLa cell lysate
PresentationMouse monoclonal IgG1 ascites containing no preservatives.
Quality LevelMQ100
Applications
ApplicationAnti-PTP-PEST Antibody, clone AG25 detects level of PTP-PEST & has been published & validated for use in WB, IP & IC.
Key Applications
  • Western Blotting
  • Immunoprecipitation
  • Immunocytochemistry
Application NotesImmunoprecipitation: Recommended.

Immunocytochemistry: Recommended.
Biological Information
ImmunogenBaculovirus expressed purified human PTP-PEST
CloneAG25
HostMouse
SpecificityRecognizes human PTP-PEST.
IsotypeIgG1
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of oncogene c-ABL, thus may play a role in oncogenesis. This PTP was shown to interact with, and dephosphorylate, various of cytoskeleton and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin, which suggested its regulatory roles in controlling cell shape and mobility.
Gene Symbol
  • PTPN12
  • PTPG1
  • PTP-PEST
  • EC 3.1.3.48
UniProt Number
UniProt SummarySIZE: 780 amino acids; 88120 Da
SUBUNIT: Interacts with TGFB1I1 (By similarity). Interacts with PSTPIP1.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE:SwissProt: Q05209 # Defects in PTPN12 are found in some colon cancers.
SIMILARITY: SwissProt: Q05209 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
Molecular Weight~88 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by Western Blot on HeLa lysates.

Western Blot Analysis: 1:500 dilution of this lot detected PTP-PEST on 10 μg of HeLa lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 1 year from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
05-1417 04053252368080

Documentation

Anti-PTP-PEST Antibody, clone AG25 MSDS

Title

Safety Data Sheet (SDS) 

Anti-PTP-PEST Antibody, clone AG25 Certificates of Analysis

TitleLot Number
Anti-PTP-PEST, clone AG25 - 2316816 2316816
Anti-PTP-PEST, clone AG25 - 3207097 3207097
Anti-PTP-PEST, clone AG25 - NG1578603 NG1578603
Anti-PTP-PEST, clone AG25 - NG1651155 NG1651155
Anti-PTP-PEST, clone AG25 - NG1698977 NG1698977
Anti-PTP-PEST, clone AG25 - NG1881305 NG1881305
Anti-PTP-PEST, clone AG25 -2514997 2514997
Anti-PTP-PEST, clone AG25 -2788178 2788178
Anti-PTP-PEST, clone AG25 -2809281 2809281
Anti-PTP-PEST, clone AG25 Monoclonal Antibody 2949949