Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB10535 Anti-Neurogenin-3 (rabbit) Antibody

Detect Neurogenin-3 (rabbit) using this Anti-Neurogenin-3 (rabbit) Antibody validated for use in WB, IH.

Anti-Neurogenin-3 (rabbit) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: NEUROG3, ATOH5, Atoh5, ngn3, NGN3, MATH4B, Math4B UniProt Number: P70661
View Products on Sigmaaldrich.com
AB10535
100 µL  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWB, IHCRbSerumPolyclonal Antibody
Description
Catalogue NumberAB10535
DescriptionAnti-Neurogenin-3 (rabbit) Antibody
Alternate Names
  • Neurogenin 3
  • NGN3
  • Neurogenin3
Background InformationNeurogenins are a family of bHLH transcription factors involved in specifying neuronal differentiation. They are related to Drosophila atonal. The neurogenins (ngns) make up one of these atonal-related gene families. In neural crest cells, the atonal-related neurogenin family is particularly important for the sensory lineage (Neurogenins Are Essential for the Formation of dorsal root ganglia), while the achaete-scute homologue ash1 (Mash1) is important for aspects of autonomic neurogenesis (mash1 is essential for noradrenergic differentiation). Neurogenin-3 also promotes pancreatic development.
References
Product Information
FormatSerum
Control
  • mNgn3 transfected and wildtype rabbit reticulocyte lysates
PresentationUnpurified rabbit polyclonal serum containing 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Neurogenin-3 (rabbit) using this Anti-Neurogenin-3 (rabbit) Antibody validated for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:500 dilution from a previous lot detected Neurogenin-3 in mouse embryo E12.5+ tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the N-terminus of mouse Neurogenin-3.
EpitopeN-terminus
HostRabbit
SpecificityThis antibody recognizes Neurogenin-3 at the N-terminus.
IsotypeIgG
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • NEUROG3
  • ATOH5
  • Atoh5
  • ngn3
  • NGN3
  • MATH4B
  • Math4B
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.

SUBUNIT STRUCTURE: Efficient DNA binding requires dimerization with another bHLH protein.

SUBCELLULAR LOCATION: Nucleus Potential.

SEQUENCE SIMILARITIES: Contains 1 basic helix-loop-helix (bHLH) domain.
Molecular Weight32 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in mNgn3 transfected and wildtype rabbit reticulocyte lysates.

Western Blot Analysis: A 1:1,000 dilution of this antibody detected Neurogenin-3 on 10 µg of mNgn3 transfected rabbit reticulocyte lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB10535 04053252517495

Documentation

Anti-Neurogenin-3 (rabbit) Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-Neurogenin-3 (rabbit) Antibody Certificates of Analysis

TitleLot Number
Anti-Neurogenin-3 (rabbit polyclonal) 2830885
Anti-Neurogenin-3 (rabbit polyclonal) 2868365
Anti-Neurogenin-3 (rabbit polyclonal) 3170252
Anti-Neurogenin-3 (rabbit polyclonal) - 2420541 2420541
Anti-Neurogenin-3 (rabbit polyclonal) - 2064316 2064316
Anti-Neurogenin-3 (rabbit polyclonal) - 2198976 2198976
Anti-Neurogenin-3 (rabbit polyclonal) - 4108585 4108585
Anti-Neurogenin-3 (rabbit polyclonal) - NG1820267 NG1820267
Anti-Neurogenin-3 (rabbit polyclonal) - NG1865074 NG1865074
Anti-Neurogenin-3 (rabbit polyclonal) - NRG1744363 NRG1744363
Show more