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MAB1892 Anti-Fibronectin Antibody, gelatin binding domain, clone IST-10

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MAB1892
100 µg  
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Overview

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB1892
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Fibronectin Antibody, gelatin binding domain, clone IST-10
Product Information
FormatPurified
PresentationPurified immunoglobulin in 0.02M phosphate buffer, 0.25M sodium chloride, 0.1% sodium azide, pH 7.6
Quality LevelMQ100
Applications
ApplicationAnti-Fibronectin Antibody, gelatin binding domain, clone IST-10 is an antibody against Fibronectin for use in WB, IH.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry

Immunoblotting: non-reducing conditions

Optimal working dilutions must be determined by end user.
Biological Information
Epitopegelatin binding domain
CloneIST-10
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityRecognizes an epitope contained within the gelatin binding domain of human fibronectin.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
Gene Symbol
  • FN1
  • DKFZp686H0342
  • DKFZp686I1370
  • MSF
  • CIG
  • LETS
  • DKFZp686O13149
  • FN
  • DKFZp686F10164
  • FINC
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P02751 # Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of cell adhesion and neurite outgrowth (By similarity).
SIZE: 2386 amino acids; 262607 Da
SUBUNIT: Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
TISSUE SPECIFICITY: Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine.DEVELOPMENTAL STAGE: Ugl-Y1, Ugl-Y2 and Ugl-Y3 are present in the urine from 0 to 17 years of age.
PTM: Sulfated.
SIMILARITY: SwissProt: P02751 ## Contains 12 fibronectin type-I domains. & Contains 2 fibronectin type-II domains. & Contains 16 fibronectin type-III domains.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain between 2 and 8°C .
Packaging Information
Material Size100 µg
Global Trade Item Number
Catalogue Number GTIN
MAB1892 04053252318900