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ABE1028 Anti-E3 ubiquitin-protein ligase UHRF2 Antibody

Anti-E3 ubiquitin-protein ligase UHRF2 Antibody is an antibody against E3 ubiquitin-protein ligase UHRF2 for use in Immunohistochemistry and Immunocytochemistry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: UHRF2, NIRF, RNF107 UniProt Number: Q96PU4
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ABE1028
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABE1028
DescriptionAnti-E3 ubiquitin-protein ligase UHRF2 Antibody
Alternate Names
  • E3 ubiquitin-protein ligase UHRF2
  • Np95/ICBP90-like RING finger protein
  • Np95-like RING finger protein
  • Nuclear protein 97
  • Nuclear zinc finger protein Np97
  • RING finger protein 107
  • Ubiquitin-like PHD and RING finger domain-containing protein 2
  • Ubiquitin-like-containing PHD and RING finger domains protein 2
  • UHRF2
Background InformationUHRF2 plays a critical role in cell cycle as it ubiquitinates cyclins and induces G1 arrest. UHRF2 also participates in epigenetic control of gene expression in many cells through binding and ubiquitinating DNA and histone binding proteins and targeting them for degradation. UHRF2 binds methylated CpG containing oligonucleotides as well and interacts directly with histone H3 as well as the trimethylated form of H3. UHRF2 is also recruited to areas of DNA damage and is important for DNA stability. UHRF2 is localized in the nucleus in heterochromatin. UHRF2 up regulated expression is associated with various cancers, however typically as mutated or lower copy number forms, which appear to has impaired anti-proliferation abilities.
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-E3 ubiquitin-protein ligase UHRF2 Antibody is an antibody against E3 ubiquitin-protein ligase UHRF2 for use in Immunohistochemistry and Immunocytochemistry.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected E3 ubiquitin-protein ligase UHRF2 in human testis and human kidney tissue.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the region required for interaction with histone H3 and interaction with PCNP of human E3 ubiquitin-protein ligase UHRF2.
EpitopeRegion required for interaction with histone H3 and interaction with PCNP
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • UHRF2
  • NIRF
  • RNF107
Purification MethodAffinity Purfied
UniProt Number
Molecular Weight~58 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in WI-38 cell lysate.

Western Blotting Analysis: A 1:5,000 dilution of this antibody detected E3 ubiquitin-protein ligase UHRF2 in 10 µg of WI-38 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABE1028 04055977135220

Documentation

Anti-E3 ubiquitin-protein ligase UHRF2 Antibody MSDS

Title

Safety Data Sheet (SDS) 

Anti-E3 ubiquitin-protein ligase UHRF2 Antibody Certificates of Analysis

TitleLot Number
Anti-E3 ubiquitin-protein ligase UHRF2 - 3904356 3904356
Anti-E3 ubiquitin-protein ligase UHRF2 -Q2550838 Q2550838

Brochure

Title
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

Technical Info

Title
White Paper: Further considerations of antibody validation and usage.