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AB10088 Anti-CYP450 1A1 Antibody

This Anti-CYP450 1A1 Antibody is validated for use in WB for the detection of CYP450 1A1.

Anti-CYP450 1A1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Enzymes & Biochemistry Gene Symbol: CYP1A1, CP11, P1-450, CYPIA1, P450-C, CYP1, P450DX, P450-P1, AHRR, AHH UniProt Number: P04798
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AB10088
50 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB10088
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-CYP450 1A1 Antibody
Alternate Names
  • Cytochrome P450
References
Product Information
FormatSerum
PresentationRaw Rabbit Serum with 0.1% Sodium Azide
Quality LevelMQ100
Applications
ApplicationThis Anti-CYP450 1A1 Antibody is validated for use in WB for the detection of CYP450 1A1.
Key Applications
  • Western Blotting
Biological Information
ImmunogenRecombinant CYP450 1A1
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
Gene Symbol
  • CYP1A1
  • CP11
  • P1-450
  • CYPIA1
  • P450-C
  • CYP1
  • P450DX
  • P450-P1
  • AHRR
  • AHH
Purification MethodSerum
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P04798 # Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
SIZE: 512 amino acids; 58165 Da
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Lung, lymphocytes and placenta.
SIMILARITY: SwissProt: P04798 ## Belongs to the cytochrome P450 family.
Molecular Weight58 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by immunoblot.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions1 year at 2-8°C from date of shipment
Packaging Information
Material Size50 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB10088 04053252581335

Documentation

Anti-CYP450 1A1 Antibody MSDS

Title

Safety Data Sheet (SDS) 

References

Reference overviewPub Med ID
Modulation of UDP-glucuronosyltransferase 1A1 in primary human hepatocytes by prototypical inducers
Smith, Cornelia M, et al
J Biochem Mol Toxicol, 19:96-108 ()  2005

15849716 15849716
Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo
Thapliyal, R and Maru, G B
Food Chem Toxicol, 39:541-7 (2001)  2001

11346483 11346483